In vitro effects of lidocaine hydrochloride on coronary artery bypass grafts

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dc.authoridCAKIR, HABIB/0000-0002-9968-5198
dc.authoridKaradag, Cetin Hakan/0000-0002-4763-986X
dc.authorwosidCAKIR, HABIB/HNB-7714-2023
dc.authorwosidgur, ozcan/AAA-8847-2022
dc.authorwosidGurkan, Selami/AAA-9006-2022
dc.authorwosidKaradag, Cetin Hakan/H-4899-2013
dc.contributor.authorGur, O.
dc.contributor.authorEge, T.
dc.contributor.authorGurkan, S.
dc.contributor.authorGur, D. Ozkaramanli
dc.contributor.authorKaradag, H.
dc.contributor.authorCakir, H.
dc.contributor.authorDuran, E.
dc.date.accessioned2024-06-12T11:03:44Z
dc.date.available2024-06-12T11:03:44Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAim. Coronary artery bypass grafting (CABG) is one of the most common procedures performed to improve blood supply to myocardium. The characteristics of grafts, mechanical stress and pharmacological agents have substantial influence on the short and long term graft patency. Lidocaine is among the most frequently used antiarrhytlunic agents perioperatively. The aim of this study was to evaluate the in vitro effects of lidocaine on internal mammarian artery (IMA), radial artery (RA) and saphenous vein (SV) grafts. Methods. Using standard tissue bath techniques, responses to increasing concentrations of lidocaine hydrochloride were obtained, in segments of IMA, RA and SV grafts. Twenty patients were enrolled in the study with a total number of 48 grafts (16 for IMA, RA and SV grafts each). In vitro lidocaine concentrations between 10(-9)M and 10(-3.5)M were studied to represent therapeutic plasma concentration of 1.5-5 mcg/mL. Results. In IMA and RA grafts, lidocaine hydrochloride caused vasodilatation (40.5 +/- 1.9% and 39.1 +/- 2.6 % respectively) at concentrations between 10(-9) to 10(-7.5) M while causing a dose dependent vasoconstriction response at concentrations above 10(-7.5)M. In SV graft samples, lidocain hydrochloride caused vasodilatation (24.4 +/- 1.9 %) at concentrations between 10(-9) to 10(-7.5) M while causing dose dependent vasoconstriction at concentrations above 10(-7) M. For vasoconstriction effect, mean +/- SD values for E-max were calculated as: 120.1 +/- 6.6% in IMA, 83.35 +/- 5.06% in RA, and 154.0 +/- 13.8% in SV. The vasoconstriction in the SV samples was higher than in the RA and IMA. The mean SD LogEC(50) values were -5.15 +/- 0.27, -5.76 +/- 0.11 and -5.56 +/- 0.19 for SV, IMA and RA grafts respectively.) There was a statiscally significant differences in the Log EC50 values between SV, IMA and RA (P<0.005) Conclusion. Based on the results of our study, we conclude that, increasing doses of lidocaine in the perioperative period may cause vasospasm in IMA, RA and SV grafts. Thus, avoiding high doses may have a role in improving perioperative and long term mortality.en_US
dc.identifier.endpage669en_US
dc.identifier.issn0021-9509
dc.identifier.issn1827-191X
dc.identifier.issue5en_US
dc.identifier.pmid22669098en_US
dc.identifier.scopus2-s2.0-84868654477en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage665en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21771
dc.identifier.volume53en_US
dc.identifier.wosWOS:000310819000013en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEdizioni Minerva Medicaen_US
dc.relation.ispartofJournal Of Cardiovascular Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIn Vitroen_US
dc.subjectCoronary Artery Bypassen_US
dc.subjectLidocaineen_US
dc.subjectCoronary Vasospasmen_US
dc.subjectInternal Mammary Arteryen_US
dc.subjectAcute Myocardial-Infarctionen_US
dc.titleIn vitro effects of lidocaine hydrochloride on coronary artery bypass graftsen_US
dc.typeArticleen_US

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