Ultrastructural Distribution of Basic Fibroblast Growth Factor-Like Molecules in Peripheral Nerves

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dc.authorscopusid6602133059
dc.authorscopusid6603246084
dc.contributor.authorKayton R.J.
dc.contributor.authorAktas R.G.
dc.date.accessioned2024-06-12T10:25:09Z
dc.date.available2024-06-12T10:25:09Z
dc.date.issued1998
dc.description.abstractBasic Fibroblast Growth Factor (bFGF) is a multifunctional polypeptide which has been shown to play a pivotal role in the survival and differentiation of nerve cells. Several trophic and non-trophic functions of this protein have been suggested in peripheral nerves. In spite of ample information about the distribution and effects of bFGF in central nervous system, few data are available concerning the localization of this protein in peripheral nerves. In view of the role of bFGF in regulation of trophic and non-trophic functions, we particularly focused on the presence and precise location of bFGF in peripheral nerves at the electron microscope level. Spurr's resin embedded ultrathin sections from adult rats' sural nerves were labeled with either polyclonal (F3393-Sigma) or monoclonal antibodies (F6162-Sigma, C3316-Zymogenetics) specific for bFGF using two-step immunogold labeling method. Control samples were treated with either an equivalent volume of blocking solution (omitting the primary antibody) or an irrelevant antibody (Factor VIII, VGF, anti-histamine, anti-fibroblast 5B5). © 1998 Microscopy Society of America.en_US
dc.identifier.doi10.1017/S1431927600025630
dc.identifier.endpage1103en_US
dc.identifier.issn1431-9276
dc.identifier.scopus2-s2.0-85180326886en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1102en_US
dc.identifier.urihttps://doi.org/10.1017/S1431927600025630
dc.identifier.urihttps://hdl.handle.net/20.500.14551/16201
dc.identifier.volume4en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofMicroscopy and Microanalysisen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[Abstarct Not Available]en_US
dc.titleUltrastructural Distribution of Basic Fibroblast Growth Factor-Like Molecules in Peripheral Nervesen_US
dc.typeConference Objecten_US

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