Beneficial effects of Ebselen on corrosive esophageal burns of rats

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dc.authoridUzun, Lokman/0000-0003-0304-3789
dc.authoridHosnuter, Mubin/0000-0002-3152-7329
dc.authorwosidUzun, Lokman/S-7689-2016
dc.authorwosidHosnuter, Mubin/J-7757-2015
dc.contributor.authorOcakci, A
dc.contributor.authorCoskun, O
dc.contributor.authorTumkaya, L
dc.contributor.authorKanter, M
dc.contributor.authorGurel, A
dc.contributor.authorHosnuter, M
dc.contributor.authorUzun, L
dc.date.accessioned2024-06-12T10:59:59Z
dc.date.available2024-06-12T10:59:59Z
dc.date.issued2006
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAim: This study was evaluated to investigate the efficacy of Ebselen, which is an organoselenium compound and glutathione peroxidase mimic, on the prevention of stricture development after esophageal caustic injuries in the rat. Methods: Thirty healthy mate Wistar albino rats were utilized in this study. The rats were randomly allotted into one of three experimental groups: group A (sham) animals were uninjured. Caustic esophageal burn was created by applying 1 ml of 37.5% NaOH to the distal esophagus. Group B rats were injured but untreated. Group C rats were injured and received Ebselen (10 mg/kg/day) via the oral route. Blood and tissue samples for the biochemical and histopathological analysis were taken all rats at the end (28th day) of the experiment. Oxidative stress is believed to play a role in the pathogenesis of corrosive esophageal burns. To assess changes in the cellular antioxidant defense system, we measured the activities of antioxidant enzymes (such as glutathione peroxidase (GSHPx), superoxide dismutase (SOD), and catatase (CAT)) in esophagus homogenates. We also measured esophageal tissue malondialdehyde (MDA) levels, a marker of lipid peroxidation, to determine whether there is an imbalance between oxidant and antioxidant status. Efficacy of the treatment was assessed by measuring the stenosis index and histopathologic damage score and biochemically by determining tissue hydroxyproline content, lipid peroxidation and antioxidant enzyme levels. Results: The stenosis index in group B was significantly increased compared with group A and C (P < 0.05). The hydroxyproline Level was significantly increased in group B compared with group A and C (P < 0.05). In group B, the histopathologic damage score was significantly higher than in group C (P < 0.05). Treatment with Ebselen decreased tissue hydroxyproline levels, histological damage, and the stenosis index. Caustic esophageal burn increased the lipid peroxidation and also decreased the antioxidant enzyme levels in group B. Ebselen treatments for 28 days decreased the elevated lipid peroxidation and also increased the reduced antioxidant enzyme levels. Live weights of the rats was significantly decreased in group B compared with group A and C (P < 0.05). Conclusion: It is concluded that Ebselen has a preventive effect in the development of fibrosis and decrease the lipid peroxidation, and increase the antioxidant defense system activity in an experimental model of corrosive esophagitis in rats. (c) 2005 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijporl.2005.05.018
dc.identifier.endpage52en_US
dc.identifier.issn0165-5876
dc.identifier.issn1872-8464
dc.identifier.issue1en_US
dc.identifier.pmid15979162en_US
dc.identifier.scopus2-s2.0-29244479535en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage45en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijporl.2005.05.018
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20657
dc.identifier.volume70en_US
dc.identifier.wosWOS:000234767800007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofInternational Journal Of Pediatric Otorhinolaryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEbselenen_US
dc.subjectStrictureen_US
dc.subjectCaustic Burnen_US
dc.subjectCorrosive Esophagitisen_US
dc.subjectFibrosisen_US
dc.subjectLipid Peroxidationen_US
dc.subjectAntioxidant Enzymesen_US
dc.subjectRaten_US
dc.subjectAlkali Burnsen_US
dc.subjectInhibitionen_US
dc.subjectInjuryen_US
dc.subjectSuperoxideen_US
dc.subjectStricturesen_US
dc.subjectManagementen_US
dc.subjectCollagenen_US
dc.subjectChildrenen_US
dc.subjectTherapyen_US
dc.subjectPz-51en_US
dc.titleBeneficial effects of Ebselen on corrosive esophageal burns of ratsen_US
dc.typeArticleen_US

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