Protective effects of curcumin against gamma radiation-induced ileal mucosal damage

Basit Öğe Kaydı
dc.authoridAkpolat Ferah, Meryem/0000-0002-3419-1728;
dc.authorwosidAkpolat Ferah, Meryem/ABD-3035-2020
dc.authorwosidUZAL, Mustafa Cem/AAH-2683-2019
dc.contributor.authorAkpolat, Meryem
dc.contributor.authorKanter, Mehmet
dc.contributor.authorUzal, Mustafa Cem
dc.date.accessioned2024-06-12T11:13:22Z
dc.date.available2024-06-12T11:13:22Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe major objective of this study was to test curcumin as a potential radioprotectant for the ileum goblet cells of the rat. Wistar albino rats were used in the study. Group A was the control group and group B was the single dose radiation group. Group C was the two dose radiation group (4 days interval). The rats in groups D and E were given a daily dose of 100 mg/kg of curcumin for 14 and 18 days, respectively. During the curcumin administration period, the rats in group D were exposed to abdominal area gamma (gamma)-ray dose of 5 Gy on the 10th day and group E was exposed to same dose radiation on the 10th and 14th day. Irradiation and treatment groups were decapitated on the 4th day after exposure to single or two-dose irradiation and ileum tissues were removed for light and electron microscopic investigation. Single or two dose 5 Gy gamma-irradiation caused a marked intestinal mucosal injury in rats on the 4th day. Radiation produced increases in the number of goblet cells. Curcumin appears to have protective effects against radiation-induced damage, suggesting that clinical transfer is feasible.en_US
dc.identifier.doi10.1007/s00204-008-0352-4
dc.identifier.endpage617en_US
dc.identifier.issn0340-5761
dc.identifier.issn1432-0738
dc.identifier.issue6en_US
dc.identifier.pmid18754102en_US
dc.identifier.scopus2-s2.0-67651151146en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage609en_US
dc.identifier.urihttps://doi.org/10.1007/s00204-008-0352-4
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23518
dc.identifier.volume83en_US
dc.identifier.wosWOS:000266945900013en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofArchives Of Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRadioprotectionen_US
dc.subjectCurcuminen_US
dc.subjectIleumen_US
dc.subjectGoblet Cellen_US
dc.subjectMorphometryen_US
dc.subjectRaten_US
dc.subjectIrradiated Small-Intestineen_US
dc.subjectRat Small-Intestineen_US
dc.subjectGoblet Cellsen_US
dc.subjectRadioprotectionen_US
dc.subjectModulationen_US
dc.subjectResponsesen_US
dc.subjectNeutronen_US
dc.subjectInjuryen_US
dc.subjectRepairen_US
dc.subjectMouseen_US
dc.titleProtective effects of curcumin against gamma radiation-induced ileal mucosal damageen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu