Color and duplex doppler sonography to detect sacroiliitis and spinal inflammation in ankylosing spondylitis.: Can this method reveal response to anti-tumor necrosis factor therapy?

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dc.authorwosidCakir, Necati/AAG-7283-2019
dc.contributor.authorUnlu, Ercument
dc.contributor.authorPamuk, Omer Nuri
dc.contributor.authorCakir, Necati
dc.date.accessioned2024-06-12T10:58:06Z
dc.date.available2024-06-12T10:58:06Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective. To investigate the role of color and duplex Doppler ultrasound (CDDUS) in the detection of sacroiliac (SI) and spinal inflammation, as well as response to anti-tumor necrosis factor (TNF) therapy in patients with ankylosing spondylitis (AS). Methods. We included 39 consecutive patients with AS followed at our center and 14 healthy controls. In the AS and control groups, blood vessels in SI joints and lumbar vertebral (LV) and thoracal vertebral (TV) paraspinal areas were investigated by CDDUS. When the artery was found, the resistive index (RI) was measured by CDDUS. Disease activity characteristics (ESR, CRP, BASDAI, and BASMI) were evaluated in patients with AS. In 11 patients for whom anti-TNF therapy was indicated, CDDUS measurements were performed before and on Week 12 of therapy. Results. In patients with AS, RI values of SI joints and of LV and TV areas were lower than in controls (all p <= 0.01). In AS patients with active disease according to BASDAI, RI values of TV (p = 0.0013) and LV (p = 0.027) were significantly lower than in the inactive group. In the group with active AS, SI RI was nonsignificantly lower (p = 0.16). After anti-TNF therapy, there were significant increases in mean SI RI (p = 0.028) and LV RI (p = 0.039), and a nonsignificant increase in TV RI (p > 0.05). Conclusion. CDDUS may be an alternative, less expensive, and easier method for detecting inflammation secondary to increased SI and spinal vascularization and in evaluating response to anti-TNF therapy in AS.en_US
dc.identifier.endpage116en_US
dc.identifier.issn0315-162X
dc.identifier.issn1499-2752
dc.identifier.issue1en_US
dc.identifier.pmid17216679en_US
dc.identifier.startpage110en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19946
dc.identifier.volume34en_US
dc.identifier.wosWOS:000243467300020en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJ Rheumatol Publ Coen_US
dc.relation.ispartofJournal Of Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectColor And Duplex Doppler Ultrasonographyen_US
dc.subjectAnkylosing Spondylitisen_US
dc.subjectTumor Necrosis Factor Inhibitoren_US
dc.subjectSacroiliitisen_US
dc.subjectScoring Systemen_US
dc.subjectUltrasounden_US
dc.subjectInfliximaben_US
dc.subjectDiseaseen_US
dc.subjectJointsen_US
dc.titleColor and duplex doppler sonography to detect sacroiliitis and spinal inflammation in ankylosing spondylitis.: Can this method reveal response to anti-tumor necrosis factor therapy?en_US
dc.typeArticleen_US

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