Prognostic value of indocyanine green elimination assessed with LiMON in septic patients

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dc.contributor.authorInal, Mehmet Turan
dc.contributor.authorMemis, Dilek
dc.contributor.authorKargi, Murat
dc.contributor.authorSut, Necdet
dc.date.accessioned2024-06-12T11:03:46Z
dc.date.available2024-06-12T11:03:46Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description8th International Conference on Complexity in Acute Illness -- AUG 28-30, 2009 -- Palo Alto, CAen_US
dc.description.abstractBackground: Sepsis is the most frequent infection with high mortality rates in intensive care units (ICUs), and the prediction of outcome is important in the decision-making process. Objective: To assess the value of the Acute Physiology and Chronic Health Evaluation II (APACHE II) and indocyanin green (ICG) plasma disappearance rate (ICG-PDR) in septic patients. Design: Retrospective analysis. Measurements and Results: We analyzed 40 septic patients (17 female and 23 male; age range, 20-89 years) who were treated in our ICU. The ICG-PDR measurement and APACHE II score measurement were made within 24 hours after admission to the ICU. Indocyanine green elimination tests were conducted concurrently using the noninvasive liver function monitoring system (LiMON, Pulsion Medical Systems, Munich, Germany). A dose of 0.3 mg/kg ICG was given through a cubital fossa vein as a bolus. Results: Statistical analysis showed that ICG-PDR was significantly tower in nonsurvivors (n = 18) than in survivors (n = 22) (mean, 12.1% +/- 7.6%/min; median, 9%/min, vs mean, 21.2% +/- 10.1%/min; median, 20%/min, respectively [P = .004]). The area under the curve as a measure of accuracy was 0.765 for ICG-PDR and 0.692 for APACHE II. Mortality was 80% in patients with ICG-PDR below 8% per minute, and survival was approximately 89% in patients with ICG-PDR above 24% per minute. Conclusion: The results suggest that ICG-PDR, assessed with a user-friendly noninvasive bedside LiMON device, is a good predictor of survival in septic patients. Sensitivity and specificity of the noninvasive measurement of ICG-PDR on ICU admission was comparable to that obtained by APACHE II scores. (C) 2009 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jcrc.2008.11.012
dc.identifier.endpage334en_US
dc.identifier.issn0883-9441
dc.identifier.issn1557-8615
dc.identifier.issue3en_US
dc.identifier.pmid19327336en_US
dc.identifier.scopus2-s2.0-67949123384en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage329en_US
dc.identifier.urihttps://doi.org/10.1016/j.jcrc.2008.11.012
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21784
dc.identifier.volume24en_US
dc.identifier.wosWOS:000268937700004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofJournal Of Critical Careen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIndocyanine Greenen_US
dc.subjectPlasma Disappearance Rateen_US
dc.subjectAcute Physiology And Chronic Health Evaluationen_US
dc.subjectPrognostic Factoren_US
dc.subjectSepsisen_US
dc.subjectPlasma Disappearance Rateen_US
dc.subjectLiver-Transplantationen_US
dc.subjectClearanceen_US
dc.subjectSepsisen_US
dc.subjectPerfusionen_US
dc.subjectApacheen_US
dc.subjectShocken_US
dc.titlePrognostic value of indocyanine green elimination assessed with LiMON in septic patientsen_US
dc.typeConference Objecten_US

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