Significance of insulin-like growth factor-I expression in bladder tumors

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dc.authorscopusid24335668100
dc.authorscopusid22979793100
dc.authorscopusid20735640800
dc.authorscopusid13609545500
dc.authorscopusid7801455897
dc.authorscopusid6508269063
dc.contributor.authorÖzbakir F.
dc.contributor.authorKaplan M.
dc.contributor.authorUsta U.
dc.contributor.authorAktoz T.
dc.contributor.authorAtakan I.H.
dc.contributor.authorInci O.
dc.date.accessioned2024-06-12T10:28:44Z
dc.date.available2024-06-12T10:28:44Z
dc.date.issued2008
dc.description.abstractIntroduction: Insulin-like growth factor-I is a mitogenic peptide which overexpression involved in the aberrant cell proliferation and malign transformation. It was thought that it can show the malign behavior of bladder tumors. Our aim in this study is to investigate the relationship between insulin like growth factor expression and tumor grade, stage and recurrence in patients with bladder tumor. Materials and Methods: 53 patients that performed transurethral tumor resection or radical cystectomy between 2002 and 2007 were included in this study. Insulin like growth factor-1 staining was determined by immunohistochemically from the bladder tumor tissue. Then we investigated the relationship between insulin like growth factor expression in bladder tumor tissue and tumor grade, stage, and recurrence. Results: The mean age was 64.4±11.9, 32 patients have low grade, 21 have high grade; 35 have superficial, 18 have muscle invasive tumor. Of 35 patients with superficial tumors, 25 patients have regular follow-up and the mean follow-up duration was 21.9±8.1 month. There was no significant difference in insulin-like growth faetor-I staining degree between low grade and high grade tumors. Insulin-like growth factor-I staining degree was same in both superficial and muscle invasive tumors. We found no relationship between recurrence and insulin-like growth factor-I staining degree. Conclusion: We found no association between tumor grade, stage, and recurrence and insulin-like growth factor-I staining degree in bladder tumors.en_US
dc.identifier.endpage14en_US
dc.identifier.issn1300-5804
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-44449083222en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage9en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17387
dc.identifier.volume34en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofTurk Uroloji Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBladder Tumor; Insulin-Like Growth Factor-I; Recurrenceen_US
dc.titleSignificance of insulin-like growth factor-I expression in bladder tumorsen_US
dc.title.alternativeMesane tümörlerinde insülin benzeri büyüme etkeni-I ekspresyonunun önemien_US
dc.typeArticleen_US

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