Synthesis of Novel Oxime and Benzofuran Chemical Frameworks Possessing Potent Anticholinesterase Activity: A SAR Study Related to Alzheimer Disease

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dc.authoridYILMAZ, ANIL/0000-0002-0704-6306
dc.authoridKoca, Murat/0000-0002-9250-0293
dc.authorwosidKoca, Murat/KGM-2351-2024
dc.contributor.authorYilmaz, Anil
dc.contributor.authorKoca, Murat
dc.contributor.authorBoga, Mehmet
dc.contributor.authorKurt, Adnan
dc.contributor.authorOzturk, Turan
dc.date.accessioned2024-06-12T10:51:21Z
dc.date.available2024-06-12T10:51:21Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAlzheimer Disease (AD) is a neurological disorder that causes the brain to shrink and brain cells to eventually die. Main symptom of AD is dementia. Today, approximately 50 million people worldwide are estimated to have AD. However, there is not a determined cure known against AD today. There are just four drugs against AD on the market. Unfortunately, none of them can totally destroy AD. Thus, discovering new molecules having capability to treat AD is required and significant. Benzofurans and oximes demonstrate a number of biological effects including anti-inflammatory and brain-barrier penetrating. For this reason, a number of novel compounds bearing oxime and benzofuran skeletons were designed and synthesized, and their anticholinesterase activities were investigated. Based on the results, several molecules demonstrated very strong anticholinesterase activities against both AChE and BChE enzymes, even much better than the reference drug molecule, Galantamine. Besides, structure-activity relationship (SAR) studies belonging to these chemical cores were revealed through this study for the first time. Various derivatives with different types of selective activities were obtained, which brightens the detailed SAR tendency of these molecules. This study can contribute to discover a novel lead drug molecule against AD, which is an urgent need.en_US
dc.identifier.doi10.1002/slct.202302058
dc.identifier.issn2365-6549
dc.identifier.issue30en_US
dc.identifier.scopus2-s2.0-85167342263en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/slct.202302058
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18335
dc.identifier.volume8en_US
dc.identifier.wosWOS:001045166200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofChemistryselecten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlzheimeren_US
dc.subjectAnticholinesteraseen_US
dc.subjectBenzofuranen_US
dc.subjectOximeen_US
dc.subjectStructure-Activity Relationshipen_US
dc.subjectDerivativesen_US
dc.subjectAlysineen_US
dc.titleSynthesis of Novel Oxime and Benzofuran Chemical Frameworks Possessing Potent Anticholinesterase Activity: A SAR Study Related to Alzheimer Diseaseen_US
dc.typeArticleen_US

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