HISTOPATHOLOGICAL AND SCINTIGRAPHIC COMPARISONS OF THE PROTECTIVE EFFECTS OF l-CARNITINE AND AMIFOSTINE AGAINST RADIATION-INDUCED LATE RENAL TOXICITY IN RATS

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dc.authoridDURMUS ALTUN, GULAY/0000-0002-1822-9386
dc.authoridPuyan, Fulya/0000-0001-5853-0109
dc.authoridCosar, Rusen/0000-0002-7953-8887
dc.authoridCosar, Rusen/0000-0002-7953-8887
dc.authoridOz Puyan, Fulya/0000-0001-5853-0109
dc.authoridPARLAR, SULE/0000-0001-9422-853X
dc.authorwosidDURMUS ALTUN, GULAY/S-6586-2016
dc.authorwosidPuyan, Fulya/V-7074-2019
dc.authorwosidCosar, Rusen/AAC-4045-2020
dc.authorwosidCosar, Rusen/GQP-7875-2022
dc.authorwosidOz Puyan, Fulya/A-7077-2018
dc.contributor.authorCaloglu, Murat
dc.contributor.authorYurut-Caloglu, Vuslat
dc.contributor.authorDurmus-Altun, Gulay
dc.contributor.authorOz-Puyan, Fulya
dc.contributor.authorUstun, Funda
dc.contributor.authorCosar-Alas, Rusen
dc.contributor.authorSaynak, Mert
dc.date.accessioned2024-06-12T10:51:24Z
dc.date.available2024-06-12T10:51:24Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of the present study was to compare the protective effects of l-carnitine and amifostine against radiation-induced late nephrotoxicity using technetium-99m diethylenetriaminepentaacetic acid scintigraphy and histopathological examination. Seventy-one Albino rats were randomly divided into six groups as follows: (i) AMI + RAD (n = 15), 200 mg/kg, i.p., amifostine 30 min prior to irradiation (a single dose of 9 Gy); (ii) LC + RAD (n = 15), 300 mg/kg, i.p., l-carnitine 30 min prior to irradiation; (iii) LC (n = 10), 300 mg/kg, i.p., l-carnitine 30 min prior to sham irradiation; (iv) AMI (n = 10), 200 mg/kg, i.p., amifostine 30 min prior to sham irradiation; RAD (n = 11), 1 mL/kg, i.p., normal saline 30 min prior to irradiation; and (vi) control (n = 10), 1 mL/kg, i.p., normal saline 30 min prior to sham irradiation. Scintigraphy was performed before treatment and again 6 months after treatment. Kidneys were examined by light microscopy and a histopathological scoring system was used to assess the degree of renal damage. The main histopathological findings were proximal tubular damage and interstitial fibrosis. Glomerular injury was similar in all groups. Tubular degeneration and atrophy were less common in the AMI + RAD group than in the RAD group (P = 0.011 and P = 0.015, respectively), as well as in the LC + RAD group compared with the RAD group (P = 0.028 and P = 0.036, respectively). Interstitial fibrosis in the AMI + RAD and LC + RAD groups was significantly less than that in the RAD group (P = 0.015 and P = 0.015, respectively). The highest total renal injury score (9) was seen in the RAD group. On scintigraphy, there were significant differences in post-treatment time to peak count (T(max)) and time from peak count to half count (T(1/2)) values (P = 0.01 and 0.02, respectively) between groups in the right kidney. In the control and RAD groups, the T(1/2) of the right kidney was 8 +/- 2 and 21 +/- 2 min, respectively. The T(max) values for the AMI + RAD and LC + RAD groups (2.8 +/- 0.2 and 3.2 +/- 0.2 min, respectively) were similar to those in the control group (2.5 +/- 0.3 min). Based on the results of the present study, l-carnitine and amifostine have comparable and significant protective effects against radiation-induced late nephrotoxicity.en_US
dc.identifier.doi10.1111/j.1440-1681.2008.05103.x
dc.identifier.endpage530en_US
dc.identifier.issn0305-1870
dc.identifier.issue5-6en_US
dc.identifier.pmid19673935en_US
dc.identifier.scopus2-s2.0-65349172318en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage523en_US
dc.identifier.urihttps://doi.org/10.1111/j.1440-1681.2008.05103.x
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18354
dc.identifier.volume36en_US
dc.identifier.wosWOS:000265549200011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwell Publishing, Incen_US
dc.relation.ispartofClinical And Experimental Pharmacology And Physiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmifostineen_US
dc.subjectL-Carnitineen_US
dc.subjectHistopathologyen_US
dc.subjectKidneyen_US
dc.subjectNephrotoxicityen_US
dc.subjectRadiationen_US
dc.subjectRadioprotectionen_US
dc.subjectRaten_US
dc.subjectScintigraphyen_US
dc.subjectInduced Oxidative Stressen_US
dc.subjectL-Propionyl-Carnitineen_US
dc.subjectMouse Kidneyen_US
dc.subjectInduced Nephrotoxicityen_US
dc.subjectRetrospective Analysisen_US
dc.subjectIrradiated Ratsen_US
dc.subjectVitamin-Een_US
dc.subjectInjuryen_US
dc.subjectDamageen_US
dc.subjectNephropathyen_US
dc.titleHISTOPATHOLOGICAL AND SCINTIGRAPHIC COMPARISONS OF THE PROTECTIVE EFFECTS OF l-CARNITINE AND AMIFOSTINE AGAINST RADIATION-INDUCED LATE RENAL TOXICITY IN RATSen_US
dc.typeArticleen_US

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