Acute sleep deprivation immediately increases serum GDNF, BDNF and VEGF levels in healthy subjects

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dc.authoridGorgulu, Yasemin/0000-0002-3401-4879
dc.authorwosidGorgulu, Yasemin/S-4355-2017
dc.contributor.authorGorgulu, Yasemin
dc.contributor.authorCaliyurt, Okan
dc.contributor.authorCinar, Rugul Kose
dc.contributor.authorSonmez, Mehmet Bulent
dc.date.accessioned2024-06-12T11:02:31Z
dc.date.available2024-06-12T11:02:31Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAcute sleep deprivation upregulates hippocampal neurogenesis. Neurotrophic factors such as glial cell line-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), and vascular endothelial growth factor (VEGF) are mediators of neuronal plasticity and neurogenesis. These neurotrophins are involved in sleep and sleep disorders and are associated with sleep deprivation. In this study, it is aimed to investigate the changes of neurotrophin levels with total sleep deprivation in healthy individuals. Seventeen healthy young adults with a mean age of 19.8 (SD = 1.0) years underwent an experimental protocol consisting of 36 h of total sleep deprivation. Venous blood samples were obtained on Day1 at 09.00, on Day2 at 09.00, and at 21.00. Serum levels of neurotrophins were detected using the ELISA method. The participants were asked to mark the scores corresponding to their subjective energy, happiness, depression, tension levels on the visual analog scale; and sleepiness level on the Epworth Sleepiness Scale; during the course of the study. As a result of 36 h of sleep deprivation, serum GDNF, BDNF, and VEGF levels showed a statistically significant increase compared to the baseline values in the participants included in the study (P < 0.0001). While this increase was evident in 24 h, it continued after 36 h. In parallel, sleepiness levels, subjective depression, and tension levels increased, on the other hand, subjective energy and happiness scores decreased at a statistically significant level at the end of the study compared to basal values (P < 0.0001). The results show that acute sleep deprivation significantly affects and increases serum levels of neurotrophic factors, and it seems that these effects are likely to occur as an immediate response to the stress and disruption caused by sleep deprivation.en_US
dc.description.sponsorshipTrakya University Scientific Research Project Committeeen_US
dc.description.sponsorshipThis work was supported by a research grant from Trakya University Scientific Research Project Committee (Grant number: TUTF-BAEK 2015/44). The Trakya University Scientific Research Project Committee provided financial support for the conduct of the research. This committee evaluates the researches and provides financial support for the ones that they see relevant for the scientific improvement of the university. This work was not an industry-supported study. Each author declares that they have no financial conflict of interest.en_US
dc.identifier.doi10.1007/s41105-021-00341-w
dc.identifier.endpage79en_US
dc.identifier.issn1446-9235
dc.identifier.issn1479-8425
dc.identifier.issue1en_US
dc.identifier.pmid38469072en_US
dc.identifier.scopus2-s2.0-85110164838en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage73en_US
dc.identifier.urihttps://doi.org/10.1007/s41105-021-00341-w
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21309
dc.identifier.volume20en_US
dc.identifier.wosWOS:000673836200001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Japan Kken_US
dc.relation.ispartofSleep And Biological Rhythmsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGDNFen_US
dc.subjectBDNFen_US
dc.subjectVEGFen_US
dc.subjectSleep Deprivationen_US
dc.subjectGrowth-Factor Vegfen_US
dc.subjectNeurotrophic Factorsen_US
dc.subjectNeurogenesisen_US
dc.subjectDepressionen_US
dc.subjectPlasticityen_US
dc.subjectCortisolen_US
dc.subjectMarkersen_US
dc.subjectBrainen_US
dc.subjectRatsen_US
dc.titleAcute sleep deprivation immediately increases serum GDNF, BDNF and VEGF levels in healthy subjectsen_US
dc.typeArticleen_US

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