Investigation of Relationship Between Small Noncoding RNA (sncRNA) Expression Levels and Serum Iron, Copper, and Zinc Levels in Clinical Diagnosed Multiple Sclerosis Patients

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dc.authoridAlkanli, Nevra/0000-0002-3745-8838
dc.authoridGurkan, Hakan/0000-0002-8967-6124
dc.authorwosidAlkanli, Nevra/D-4400-2019
dc.contributor.authorAy, Arzu
dc.contributor.authorAlkanli, Nevra
dc.contributor.authorAtli, Engin
dc.contributor.authorGurkan, Hakan
dc.contributor.authorGulyasar, Tevfik
dc.contributor.authorGuler, Sibel
dc.contributor.authorSipahi, Tammam
dc.date.accessioned2024-06-12T11:08:48Z
dc.date.available2024-06-12T11:08:48Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIn our study, we aimed to investigate the relationship between microRNA (miRNA) expression levels and serum iron (Fe), copper (Cu), and zinc (Zn) levels in Multiple sclerosis (MS) patients. Total RNA was isolated from peripheral venous blood containing ethylenediaminetetraacetic acid (EDTA) of MS patients and controls. Total RNA was labeled with Cy3-CTP fluorescent dye. Hybridization of samples was performed on microarray slides and arrays were scanned. Data argument and bioinformatics analysis were performed. Atomic absorption spectrophotometer method was used to measure serum Fe, Cu, and Zn levels. In our study, in bioinformatics analysis, although differently expressed miRNAs were not detected between 16 MS patients and 16 controls, hsa-miR-744-5p upregulation was detected between 4 MS patients and 4 controls. This may be stem from the patient group consisting of MS patients who have never had an attack for 1 year. Serum iron levels were detected significantly higher in the 16 MS patients compared to the 16 controls. This may be stem from the increase in iron accumulation based on inflammation in MS disease. According to the findings in our study, hsa-miR-744-5p upregulation has been determined as an early diagnostic biomarker for the development together of insulin resistance, diabetes mellitus associated with insulin signaling, and Alzheimer's diseases. Therefore, hsa-miR-744-5p is recommended as an important biomarker for the development together of diabetes mellitus, Alzheimer's disease, and MS disease. In addition, increased serum Fe levels may be suggested as an important biomarker for neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, and MS disease.en_US
dc.description.sponsorshipCoordinatorship of Scientific Research Projects of Trakya University [2017/68]en_US
dc.description.sponsorshipThis study was supported by the Coordinatorship of Scientific Research Projects of Trakya University with 2017/68 project number.en_US
dc.identifier.doi10.1007/s12035-022-03135-4
dc.identifier.endpage883en_US
dc.identifier.issn0893-7648
dc.identifier.issn1559-1182
dc.identifier.issue2en_US
dc.identifier.pmid36383327en_US
dc.identifier.scopus2-s2.0-85141973743en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage875en_US
dc.identifier.urihttps://doi.org/10.1007/s12035-022-03135-4
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22574
dc.identifier.volume60en_US
dc.identifier.wosWOS:000884637800001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular Neurobiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMultiple Sclerosisen_US
dc.subjectMicrornasen_US
dc.subjectTrace Elementsen_US
dc.subjectSpectrophotometryen_US
dc.subjectAtomicen_US
dc.subjectBioinformatic Analysisen_US
dc.subjectTrace-Elementsen_US
dc.subjectBiomarkersen_US
dc.subjectMicrornasen_US
dc.subjectBlooden_US
dc.titleInvestigation of Relationship Between Small Noncoding RNA (sncRNA) Expression Levels and Serum Iron, Copper, and Zinc Levels in Clinical Diagnosed Multiple Sclerosis Patientsen_US
dc.typeArticleen_US

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