The effect of Amifostine (Ethyol) on intestinal anastomosis in rats with radiation enteritis

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dc.authoridOZCELIK, MEHMET FAIK/0000-0002-5249-7106
dc.authorwosidOZCELIK, MEHMET FAIK/AAA-3384-2022
dc.contributor.authorOzdemir, C. S.
dc.contributor.authorBurgazli, K. M.
dc.contributor.authorBeken-Ozdemir, E.
dc.contributor.authorAkdere, H.
dc.contributor.authorMericliler, M.
dc.contributor.authorOzcelik, M. F.
dc.date.accessioned2024-06-12T10:51:23Z
dc.date.available2024-06-12T10:51:23Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBACKGROUND: Preoperative radiotherapy in colorectal cancers is being used as an adjuvant therapy with increasing frequency. Postoperative complications in early and late periods in various ratios are reported. It has also been shown that radiation has a delaying effect on wound healing and this effect is dose-dependent. AIM: This study investigated the effects of the Amifostine on healing of the irradiated colonic anastomosis. MATERIALS AND METHODS: 30 female Wistar rats were divided randomly into three groups equally (n=10). Colonic anastomosis were performed to all rats. Group I served as a control. 800 rad abdominopelvic irradiation on the 5th day of preoperation was given to group II and III. Rats in the group III, prior to radiation, were given Amifostine at a dose of 200 mg/kg. On the 5th postoperative day all the rats were sacrificed and the healing of anastomosis was measured with bursting pressure, hydroxyproline levels and histopathological evaluations. Statistical analyses were expressed by analysis of variance (ANOVA) test and p < 0.05 was regarded as significant. RESULTS: In group II, all parameters were found lower compared with control group and Amifostine+Radiation group. As compared with hydroxyproline values and the anastomotic wound healing scores, except group II, no significantly difference were determined between the two other groups. In bursting pressure levels, Group I and III were higher than group II, but not statistically significant (p > 0.05). In group III (Amifostine+Radiation group), the hydroxyproline levels and anastomotic wound healing scores were found significantly higher than group II (p < 0.05), and no significant difference were found between the control group. CONCLUSIONS: It is determined that radiation given on the 5th preoperative day has a negative effect on anastomotic wound healing and administered Amifostine prevent this negative effect. In the light of these data, the Amifostine may have a positive effect on preoperative irradiated colonic anastomosis and may play an important role in future on the supporting of the colonic anastomosis.en_US
dc.identifier.endpage1359en_US
dc.identifier.issn1128-3602
dc.identifier.issue10en_US
dc.identifier.pmid23740449en_US
dc.identifier.scopus2-s2.0-84878601154en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1351en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18351
dc.identifier.volume17en_US
dc.identifier.wosWOS:000324922900010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical And Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmifostineen_US
dc.subjectIntestinal Anastomosisen_US
dc.subjectRadiationen_US
dc.subjectWound Healingen_US
dc.subjectPreoperative Radiotherapyen_US
dc.subjectExperimental Colonic Anastomosesen_US
dc.subjectPreoperative Irradiationen_US
dc.subjectColorectal-Canceren_US
dc.subjectHealing-Processen_US
dc.subjectHydroxyprolineen_US
dc.subjectRadiotherapyen_US
dc.subjectProtectionen_US
dc.subjectResectionen_US
dc.subjectWr-2721en_US
dc.subjectCellsen_US
dc.titleThe effect of Amifostine (Ethyol) on intestinal anastomosis in rats with radiation enteritisen_US
dc.typeArticleen_US

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