The effectiveness of splenic autotransplantation: An experimental study

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dc.authorscopusid14321958500
dc.authorscopusid6507904540
dc.authorscopusid36979382700
dc.authorscopusid7101694726
dc.authorscopusid6603174559
dc.contributor.authorKaragülle E.
dc.contributor.authorHoşcoşkun Z.
dc.contributor.authorKutlu A.K.
dc.contributor.authorKaya M.
dc.contributor.authorBaydar S.
dc.date.accessioned2024-06-12T10:29:24Z
dc.date.available2024-06-12T10:29:24Z
dc.date.issued2007
dc.description.abstractBACKGROUND: The purpose of this study was to establish the effects of spleen autotransplantation on immunity and to examine the viability of autotransplanted spleen tissue. METHODS: Three groups were assigned and following operations were performed in twenty New Zealand rabbits. 1st group: sham laparotomy, 2nd group: splenectomy and 3rd group: splenectomy and splenic autotransplantation. Scintigraphic methods, hematological-immunological tests and histopathological examination were used to evaluate the effects of splenic autotransplantation. RESULTS: Histopathological findings showed that eight rabbits had splenic regrowth and two had necrosis of autotransplanted splenic tissue. Preoperative hematological and immunological findings compared with those at sixth week postoperatively. In group 3, postoperative immunoglobulin G, immunoglobulin M and interleukin-1 levels were significantly increased when compared with preoperative levels. Between all groups, postoperative leukocyte counts were found to be significantly higher in group 2 comparing with group 1. In group 2, postoperative platelet counts were significantly higher in comparison to group 1 and 3. No statistically significant difference was detected between the groups for immunoglobulin G, immunoglobulin M and interleukin-1 levels. CONCLUSION: Conservative treatment is important in patients with splenic injury. However when splenectomy is indicated, splenic autotransplantation into the omentum pouch could be a reliable method for reconstruction of splenic functions and the viability of the implanted spleen tissue can be monitored by scintigraphy and laboratory examination.en_US
dc.identifier.endpage19en_US
dc.identifier.issn1306-696X
dc.identifier.issue1en_US
dc.identifier.pmid17310406en_US
dc.identifier.scopus2-s2.0-33846470490en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage13en_US
dc.identifier.trdizinid69790en_US
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/69790
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17750
dc.identifier.volume13en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofUlusal Travma ve Acil Cerrahi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectReticuloendothelial System; Scintigraphy; Spleen/Physiology; Spleen/Surgery/Transplantation; Splenectomy/Adverse Effectsen_US
dc.subjectImmunoglobulin G; Immunoglobulin M; Interleukin 1; Animal Experiment; Article; Autotransplantation; Blood Examination; Controlled Study; Female; Histopathology; Immunological Procedures; Laparotomy; Leukocyte Count; Nonhuman; Preoperative Evaluation; Rabbit; Scintigraphy; Spleen Transplantation; Splenectomy; Tissue Growth; Tissue Necrosis; Animals; Female; Immunoglobulin G; Immunoglobulin M; Interleukin-1; Leukocyte Count; Organ Transplantation; Platelet Count; Rabbits; Radionuclide Imaging; Regeneration; Spleen; Splenectomy; Transplantation, Autologousen_US
dc.titleThe effectiveness of splenic autotransplantation: An experimental studyen_US
dc.typeArticleen_US

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