The G1057D polymorphism of insulin receptor substrate-2 associated with gestational diabetes mellitus

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dc.authoridkarakaş çelik, sevim/0000-0003-0505-7850
dc.authoridAYAZ, LOKMAN/0000-0002-2876-055X
dc.authorwosidkarakaş çelik, sevim/C-3773-2018
dc.authorwosidAYAZ, LOKMAN/K-6716-2013
dc.contributor.authorAyaz, Lokman
dc.contributor.authorCelik, Sevim Karakas
dc.contributor.authorCayan, Filiz
dc.date.accessioned2024-06-12T11:02:23Z
dc.date.available2024-06-12T11:02:23Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: The Gly1057D polymorphism in the insulin receptor substrate-2 (IRS-2) gene has been reported to be associated with insulin resistance, obesity and type 2 diabetes; little is known about its possible association with gestational diabetes mellitus (GDM). To investigate this association we determined the distribution of its genotypes and frequency of alleles in GDM patients. Materials and methods: The study population consisted of 94 subjects; among them were 44 patients with GDM and 50 healthy controls without diabetes. Genomic DNA was extracted from the leukocyte by high pure polymerase chain reaction (PCR) template preparation kit. Genetic polymorphism of IRS-2 G1057D was detected by using PCR-based restriction fragment-length polymorphism (RFLP). Results: For IRS-2 G1057D polymorphism, there was no significant difference in genotype distribution between GDM patients and controls. The risk for GDM was 2.97 times higher (95% CI: 0.89-9.93, p = 0.076) in the individuals with the IRS-2 DD genotype compared to the GG genotype. Also individuals with the IRS-2 D allele had a significantly higher risk of GDM compared with individuals with the IRS-2 G allele, with a relative risk of 1.86 (95% CI: 1.02-3.37, p = 0.042) for cases compared with population controls. Conclusion: These results suggest that IRS-2 1057D allele may be associated with GDM.en_US
dc.identifier.doi10.3109/09513590.2013.871516
dc.identifier.endpage168en_US
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue2en_US
dc.identifier.pmid24401133en_US
dc.identifier.scopus2-s2.0-84893095949en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage165en_US
dc.identifier.urihttps://doi.org/10.3109/09513590.2013.871516
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21265
dc.identifier.volume30en_US
dc.identifier.wosWOS:000330586000019en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofGynecological Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectG1057D Polymorphismen_US
dc.subjectGDMen_US
dc.subjectInsulin Receptor Substrate-2en_US
dc.subjectAmino-Acid Polymorphismsen_US
dc.subjectGly1057asp Polymorphismen_US
dc.subjectObese Womenen_US
dc.subjectIrs-2en_US
dc.subjectResistanceen_US
dc.subjectGeneen_US
dc.subjectPregnancyen_US
dc.subjectDisruptionen_US
dc.subjectMetabolismen_US
dc.subjectMutationsen_US
dc.titleThe G1057D polymorphism of insulin receptor substrate-2 associated with gestational diabetes mellitusen_US
dc.typeArticleen_US

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