The effect of melatonin on cadmium-induced renal injury in chronically exposed rats

Basit Öğe Kaydı
dc.authoridOz Puyan, Fulya/0000-0001-5853-0109
dc.authoridPuyan, Fulya/0000-0001-5853-0109;
dc.authorwosidOz Puyan, Fulya/A-7077-2018
dc.authorwosidPuyan, Fulya/V-7074-2019
dc.authorwosidAydogdu, Nurettin/ABH-9224-2020
dc.authorwosidKaplan, Mustafa/D-4977-2014
dc.contributor.authorKaplan, Mustafa
dc.contributor.authorAtakan, Irfan Huseyin
dc.contributor.authorAydogdu, Nurettin
dc.contributor.authorAktoz, Tevfik
dc.contributor.authorPuyan, Fulya Oz
dc.contributor.authorSeren, Gulay
dc.contributor.authorTokuc, Burcu
dc.date.accessioned2024-06-12T10:52:09Z
dc.date.available2024-06-12T10:52:09Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: This study was designed to investigate the effects of melatonin as an antioxidant, in prevention and treatment of cadmium (Cd)-induced renal toxicity in rats. Materials and methods: Fifty adult male Sprague-Dawley rats weighing 340 to 370 g were used. Renal toxicity was induced with the use of 200 mu g/ml of cadmium chloride in tap water. Ten rats were assigned to receive only tap water as the control group for three months and seven days. Two study groups were designed. To investigate the ability of melatonin to prevent Cd damage (Study 1), 10 rats received Cd and 10 rats received Cd plus 0.02% co-treatment melatonin in tap water for three months. To test whether melatonin would reverse CD-induced damage to the kidney (Study 2), 10 rats received Cd in tap water for three months+7 days, and 10 rats received Cd for three months followed by administration of high-dose (0.08%) melatonin in tap water for seven days. Results: Cadmium exposure significantly increased the kidney malondialdehyde (MDA) levels, as a marker of lipid peroxidation, decreased the kidney superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities, increased Cd concentrations in the renal cortex, but did not change glomerular filtration rate (GFR) and fractional excretion of sodium (FE-Na). In Study 1, melatonin decreased MDA levels, increased SOD, CAT and GSH-Px activities. In Study 2, melatonin decreased the kidney MDA levels, increased the SOD activity, but did not change the CAT and GSH-Px activities. Kidney accumulation of Cd did not change in both melatonin-treated groups. Histopathologically, Cd intake affected proximal tubules of the nephron more than the glomerular parts. Melatonin did not change these alterations. Conclusion: Our findings suggest that Cd-induced renal toxicity is related with oxidative stress and exogenously administrated melatonin might reduce the toxic effects of Cd on kidney without any reduction in tissue Cd burden.en_US
dc.identifier.endpage147en_US
dc.identifier.issn2149-3057
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-70349276858en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage139en_US
dc.identifier.trdizinid95507en_US
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/95507
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18593
dc.identifier.volume35en_US
dc.identifier.wosWOS:000420526200011en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal Of Urologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidantsen_US
dc.subjectCadmium/Toxicityen_US
dc.subjectGlutathioneen_US
dc.subjectKidney/Drug Effectsen_US
dc.subjectLipid Peroxidation/Drug Effectsen_US
dc.subjectMalondialdehydeen_US
dc.subjectMelatoninen_US
dc.subjectOxidative Stress/Drug Effectsen_US
dc.subjectRatsen_US
dc.subjectInduced Lipid-Peroxidationen_US
dc.subjectAntioxidant Enzymesen_US
dc.subjectInduced Hepatotoxicityen_US
dc.subjectTissue Accumulationen_US
dc.subjectOxidative Stressen_US
dc.subjectGene-Expressionen_US
dc.subjectProtective Roleen_US
dc.subjectVitamin-Een_US
dc.subjectToxicityen_US
dc.subjectGlutathioneen_US
dc.titleThe effect of melatonin on cadmium-induced renal injury in chronically exposed ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu