The effect of L-carnitine on nitric oxide metabolism in streptozotocin-induced diabetic rats

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dc.contributor.authorOzgun, Gulben Sayilan
dc.contributor.authorOzgun, Eray
dc.contributor.authorEskiocak, Sevgi
dc.contributor.authorSut, Necdet
dc.date.accessioned2024-06-12T11:15:40Z
dc.date.available2024-06-12T11:15:40Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: The aim of this study is to investigate the effect of L-carnitine on plasma and liver nitric oxide metabolism in streptozotocin-induced diabetic rats. Methods: Sprague Dawley female rats were divided randomly into following groups: control, L-carnitine, diabetes and diabetes+L-carnitine. Diabetes and diabetes+L-carnitine groups were intra-peritonally injected with a single dose of streptozotocin (40 mg/kg) prepared in the citrate buffer (pH 4.5). Other groups were injected with only citrate buffer. 72 hours after the streptozotocin injection, L-carnitine (500 mg/kg/day) was given intraperitoneally to L-carnitine and diabetes+L-carnitine groups for 15 days. Physiological saline was given intraperitoneally to the other groups for 15 days. Blood sugar (at 72 hours and the end of experiment), liver nitric oxide and inducible nitric oxide synthase, plasma nitric oxide and nitrotyrosine levels were measured. Results: Blood glucose levels in diabetic groups were higher compared with other groups. Percentage change of blood glucose in diabetes+L-carnitine group was lower compared with other groups. Also diabetes+L-carnitine group's plasma nitric oxide levels were higher than control group. Plasma nitrotyrosine levels of L-carnitine injected groups were lower than diabetes group. There was no significant difference between the levels of liver inducible nitric oxide synthase and nitric oxide in groups. Conclusion: As a result, our study showed that plasma and liver nitric oxide and liver inducible nitric oxide synthase levels aren't changed significantly but plasma nitrotyrosine levels are increased at the end of 15th day of experimental diabetes. On the other hand, our results also showed that L-carnitine causes an increase in plasma nitric oxide levels and a decrease in plasma nitrotyrosine levels whereas it has no effect on liver nitric oxide and inducible nitric oxide synthase levels.en_US
dc.identifier.doi10.5505/tjb.2014.04934
dc.identifier.endpage421en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84922452243en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage416en_US
dc.identifier.urihttps://doi.org/10.5505/tjb.2014.04934
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24024
dc.identifier.volume39en_US
dc.identifier.wosWOS:000348604900003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofTurkish Journal Of Biochemistry-Turk Biyokimya Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectStreptozotocin Diabetesen_US
dc.subjectL-Carnitineen_US
dc.subjectInducible Nitric Oxide Synthaseen_US
dc.subjectNitric Oxideen_US
dc.subjectNitrotyrosineen_US
dc.subjectAcetyl-L-Carnitineen_US
dc.subjectNitrosative Stressen_US
dc.subjectBlood-Pressureen_US
dc.subjectSynthaseen_US
dc.subjectLiveren_US
dc.subjectMellitusen_US
dc.subjectPeroxynitriteen_US
dc.subjectComplicationsen_US
dc.subjectPathogenesisen_US
dc.subjectDysfunctionen_US
dc.titleThe effect of L-carnitine on nitric oxide metabolism in streptozotocin-induced diabetic ratsen_US
dc.typeArticleen_US

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