Contribution of nociceptin/orphanin FQ receptors to the anti-nociceptive and hypothermic effects of dipyrone

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dc.authoridGunduz, Ozgur/0000-0002-2470-3021
dc.authoridUlugol, Ahmet/0000-0003-4643-1124;
dc.authorwosidGunduz, Ozgur/A-2351-2016
dc.authorwosidUlugol, Ahmet/V-9665-2019
dc.authorwosidGÜNDÜZ, Özgür/AAH-8717-2019
dc.contributor.authorErtin, Ismet Hande
dc.contributor.authorGunduz, Ozgur
dc.contributor.authorUlugol, Ahmet
dc.date.accessioned2024-06-12T10:52:02Z
dc.date.available2024-06-12T10:52:02Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground Dipyrone is one of the most commonly used non-opioid analgesic and antipyretic drug. Its anti-nociceptive and hypothermic effects have long been suspected to be centrally mediated. The involvement of the most recently discovered opioid peptide, nociceptin/orphanin FQ (N/OFQ), and its receptor (NOP) in pain transmission is controversial. It appears to be pro-nociceptive when administered supra-spinally, but exerts anti-nociceptive effects when injected spinally or systemically. Objective Investigation of the role of the N/OFQ system in paracetamol-induced anti-nociception and hypothermia led us to determine its role in the anti-nociceptive and hypothermic effects of dipyrone. Material and Methods Hot-plate and tail-flick tests were used to assess nociception, and a rectal thermometer was used to measure rectal temperature in mice. Results Mice injected with dipyrone (150, 300, 600 mg/kg, i.p.) displayed dose-related anti-nociception and hypothermia. The NOP receptor antagonist JTC-801 (3 mg/kg, i.p.), at a dose that exerted no effect when used alone, alleviated dipyrone-induced anti-nociception but did not reverse dipyrone-induced hypothermia. Conclusion We conclude that NOP receptors participate in the anti-nociceptive, but not in the hypothermic, effects of dipyrone.en_US
dc.description.sponsorshipTrakya University Research Council [TUBAP-2013/32]en_US
dc.description.sponsorshipThis work was supported by a grant from Trakya University Research Council (TUBAP-2013/32).en_US
dc.identifier.doi10.1017/neu.2014.38
dc.identifier.endpage52en_US
dc.identifier.issn1601-5215
dc.identifier.issue1en_US
dc.identifier.pmid25467825en_US
dc.identifier.scopus2-s2.0-84922718448en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage48en_US
dc.identifier.urihttps://doi.org/10.1017/neu.2014.38
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18576
dc.identifier.volume27en_US
dc.identifier.wosWOS:000349531800007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofActa Neuropsychiatricaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnti-Nociceptionen_US
dc.subjectDipyroneen_US
dc.subjectHypothermiaen_US
dc.subjectJTC-801en_US
dc.subjectNen_US
dc.subjectOFQen_US
dc.subjectEndogenous Opioidsen_US
dc.subjectCannabinoid Cb1en_US
dc.subjectChronic Painen_US
dc.subjectMiceen_US
dc.subjectRatsen_US
dc.subjectMetamizolen_US
dc.subjectAcetaminophenen_US
dc.subjectParacetamolen_US
dc.subjectInvolvementen_US
dc.subjectInhibitionen_US
dc.titleContribution of nociceptin/orphanin FQ receptors to the anti-nociceptive and hypothermic effects of dipyroneen_US
dc.typeArticleen_US

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