The investigation of killer cell immunoglobulin-like receptor genotyping in patients with systemic lupus erytematosus and systemic sclerosis

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dc.authoridGürkan, Hakan/0000-0002-8967-6124
dc.authoridEKER, DAMLA/0000-0001-7563-118X
dc.authorwosideker, damla/AAE-6947-2020
dc.authorwosidGürkan, Hakan/AAF-2866-2020
dc.contributor.authorTozkir, Julide Duymaz
dc.contributor.authorTozkir, Hilmi
dc.contributor.authorGurkan, Hakan
dc.contributor.authorDonmez, Salim
dc.contributor.authorEker, Damla
dc.contributor.authorPamuk, Gulsum Emel
dc.contributor.authorPamuk, Omer Nuri
dc.date.accessioned2024-06-12T11:02:34Z
dc.date.available2024-06-12T11:02:34Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractSystemic lupus erythematosus (SLE) is an autoimmune disease characterised by the production of autoantibodies and the involvement of multiple organ systems. Systemic sclerosis (SSc) is another autoimmune disease that causes fibrosis. We will aim to analyse the role of killer cell immunoglobulin-like receptor (KIR) genotypes and their existence with the respective HLA ligands in patients with SLE and SSc. Forty-five SLE, 25 SSc and 40 healthy controls were included. We examined the presence/absence of KIR2DL1, 2DL2, 2DL3, 2DL4, 2DL5A, 2DL5B, 2DS1, 2DS1, 2DS2, 2DS3, 2DS4, 2DS5, 3DL1, 3DL2, 3DL3, 3DS1, 2DP1, 3DP1 and their known HLA ligands. In the SLE group, the KIR2DL5, KIR2DL5B and KIR2DS3 genes were significantly more frequent, and KIR2DL3 gene was significantly less than in controls (p values < 0.05). In SSc patients, the KIR2DS3 gene was more frequent than in controls (p = 0.032). The KIR2DL3 gene was detected more frequently in controls while KIR2DS3 gene was more frequent in the patient group when SLE and SSc patients were combined (p values < 0.05). The KIR2DS2/HLA-C and KIR2DS2/HLA-C combinations were significantly more in both SLE and SSc groups than in controls. The KIR2DL2 and KIR2DL5B genes were protective from neurologic involvement in SLE patients (p values < 0.05). The variations of some KIR genes such as KIR2DL5, KIR2DL5B, KIR2DS3 and KIR2DL3 may have a role in the pathogenesis of SLE and SSc. Also, the presence of KIR2DL2 and KIR2DL5B may cause major organ involvement, like neurologic involvement, in SLE.en_US
dc.description.sponsorshipScientific And Technological Research Council Of Turkey (TUBITAK) 3501-Career Development Program [111S153]en_US
dc.description.sponsorshipThis study was supported by grants from The Scientific And Technological Research Council Of Turkey (TUBITAK) 3501-Career Development Program (Project number: 111S153). The authors acknowledge Dr. Canpolat Polat for his translational and linguistic assistance.en_US
dc.identifier.doi10.1007/s10067-016-3222-0
dc.identifier.endpage925en_US
dc.identifier.issn0770-3198
dc.identifier.issn1434-9949
dc.identifier.issue4en_US
dc.identifier.pmid26960450en_US
dc.identifier.scopus2-s2.0-84960153635en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage919en_US
dc.identifier.urihttps://doi.org/10.1007/s10067-016-3222-0
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21335
dc.identifier.volume35en_US
dc.identifier.wosWOS:000373155800012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer London Ltden_US
dc.relation.ispartofClinical Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGeneticen_US
dc.subjectKiller Cell Immunoglobulin-Like Receptors (Kirs)en_US
dc.subjectSystemic Lupus Erythematosus (SLE)en_US
dc.subjectSystemic Sclerosis (Ssc)en_US
dc.subjectAssociationen_US
dc.subjectGeneticsen_US
dc.subjectKirsen_US
dc.titleThe investigation of killer cell immunoglobulin-like receptor genotyping in patients with systemic lupus erytematosus and systemic sclerosisen_US
dc.typeArticleen_US

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