Ultrastructural changes in rat liver by methyleugenol and evaluation of some biochemical parameters

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dc.authoridCerkezkayabekir, Aysegul/0000-0001-5537-1042
dc.authoridErtan, Figen/0000-0002-7882-3993
dc.authorwosidCerkezkayabekir, Aysegul/Q-6629-2018
dc.contributor.authorCerkezkayabekir, Aysegul
dc.contributor.authorKizilay, Gulnur
dc.contributor.authorErtan, Figen
dc.date.accessioned2024-06-12T11:08:27Z
dc.date.available2024-06-12T11:08:27Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe present study investigated the effect of methyleugenol, a food flavoring and fragrance agent, on the livers of laboratory rats. Doses of 10 and 30 mg/kg/day of methyleugenol (in 0.5% methylcellulose) were administered intragastrically (IG) to 2 dose groups for 10 days alongside a control group (n = 10 for each group). Gains in body weight were not statistically significant for either dose. Lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) activities decreased (P < 0.05) for both dose groups, but AST (aspartate aminotransferase) activity decreased significantly (P < 0.05) only in the 30 mg/kg/day methyleugenol dose group. Alanine aminotransferase (ALT) activity did not change significantly in either group. The total amount of glucose remained unchanged, but glycogen in the liver decreased significantly (P < 0.05) in the 30 mg/kg/day methyleugenol dose group. There was also an increase of swelling in the smooth endoplasmic reticulum sacs (sER), electron dense accumulations in the sER, cytoplasmic vacuolization, a slight increase of mitochondria and lysosomes, and invaginations in the nucleus membranes of hepatocytes. Extensions in bile canaliculi and increasing microvilli of bile canaliculi in the liver were also observed. These findings indicate the ultrastructural toxic effect of methyleugenol on rat livers in 10 and 30 mg/kg/day doses. Therefore, we may speculate that the toxic effect of methyleugenol needs to be examined in detail.en_US
dc.description.sponsorshipTrakya University [TUAF-721]en_US
dc.description.sponsorshipThis study was supported by the Research Fund of Trakya University (Project number: TUAF-721). Statistical analyses of the data were performed by the Statistics Office of Trakya University. We thank Nesrin Turan PhD for statistical contribution.en_US
dc.identifier.doi10.3906/biy-0811-21
dc.identifier.endpage445en_US
dc.identifier.issn1300-0152
dc.identifier.issn1303-6092
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-78149242117en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage439en_US
dc.identifier.trdizinid106596en_US
dc.identifier.urihttps://doi.org/10.3906/biy-0811-21
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/106596
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22439
dc.identifier.volume34en_US
dc.identifier.wosWOS:000285179000012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMethyleugenolen_US
dc.subjectLiveren_US
dc.subjectUltrastructureen_US
dc.subjectALTen_US
dc.subjectASTen_US
dc.subjectLDHen_US
dc.subjectASPen_US
dc.subjectGlucoseen_US
dc.subjectGlycogenen_US
dc.subjectRaten_US
dc.subjectToxicityen_US
dc.subjectEugenolen_US
dc.subjectSafroleen_US
dc.subjectGenotoxicityen_US
dc.subjectDerivativesen_US
dc.subjectMetabolismen_US
dc.titleUltrastructural changes in rat liver by methyleugenol and evaluation of some biochemical parametersen_US
dc.typeArticleen_US

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