Investigation of roles of IL-8 (+781 C/T) and MMP-2 (-735 C/T) gene variations in early diagnosis of bladder cancer and progression

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dc.authoridÇevik, Gökhan/0000-0001-5221-5132
dc.authoridAlkanli, Nevra/0000-0002-3745-8838
dc.authorwosidAlkanli, Nevra/D-4400-2019
dc.authorwosidÇevik, Gökhan/GZA-3993-2022
dc.contributor.authorAlkanli, Nevra
dc.contributor.authorAy, Arzu
dc.contributor.authorCevik, Gokhan
dc.date.accessioned2024-06-12T10:54:47Z
dc.date.available2024-06-12T10:54:47Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground The aim of our study is to investigate the roles of IL-8 (+ 781 C/T) and MMP-2 (-735 C/T) gene variations in early diagnosis and progression of BCA. Methods Polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP) methods were used to determine the genotype distributions of IL-8 (+ 781 C/T) and MMP-2 (-735 C/T) gene variations. Results In our study, the genotype distributions of IL-8 (+ 781 C/T) and MMP-2 (-735 C/T) gene variations were not found to be significantly different between the patient and control groups. In addition, C and T allele frequencies for these gene variations were not different from the Hardy-Weinberg distribution in patient and control groups. However, when the combined genotype analyzes for these gene variations were evaluated, CC-CC and CT-CC combined genotypes for + 781 C/T / -735 C/T gene variations were observed significantly more in the patient group compared to other genotypes. Conclusion Although IL-8 (+ 781 C/T) and MMP-2 (-735 C/T) gene variations were not found to be genetic risk factors in the Thrace population in our study, CC-CC and CT-CC combined genotypes were determined as genetic risk factors for BCA susceptibility. The combined genotypes obtained as a result of the combined genotype analysis of these genetic variations that are effective in tumor progression may be considered to be important biomarkers for the early diagnosis and progression of BCA.en_US
dc.identifier.doi10.1007/s11033-022-07881-5
dc.identifier.endpage451en_US
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue1en_US
dc.identifier.pmid36348195en_US
dc.identifier.scopus2-s2.0-85141579174en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage443en_US
dc.identifier.urihttps://doi.org/10.1007/s11033-022-07881-5
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19180
dc.identifier.volume50en_US
dc.identifier.wosWOS:000880268100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular Biology Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBladder Canceren_US
dc.subjectMatrix Metalloproteinaseen_US
dc.subjectInterleukinen_US
dc.subjectGene Variationsen_US
dc.subjectPCR-RFLPen_US
dc.subjectOncologic Outcomesen_US
dc.subjectLung-Canceren_US
dc.subjectPolymorphismsen_US
dc.subjectRisken_US
dc.subjectSusceptibilityen_US
dc.subjectInterleukin-8en_US
dc.subjectAssociationen_US
dc.subjectIl-8-251a/Ten_US
dc.titleInvestigation of roles of IL-8 (+781 C/T) and MMP-2 (-735 C/T) gene variations in early diagnosis of bladder cancer and progressionen_US
dc.typeArticleen_US

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