The fate of intramuscularly injected fat autografts: An experimental study in rabbits

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dc.contributor.authorAygit, AC
dc.contributor.authorSarikaya, A
dc.contributor.authorDoganay, L
dc.contributor.authorTop, H
dc.contributor.authorCakir, B
dc.contributor.authorFirat, MF
dc.date.accessioned2024-06-12T11:02:16Z
dc.date.available2024-06-12T11:02:16Z
dc.date.issued2004
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAn experimental study was designed to assess the viability and revascularization of intramuscularly injected fat autografts. For the study, 18 rabbits were divided into two groups. In the first group, fat was injected intramuscularly (12 rabbits). Autologous fat was obtained from the inguinal area and subsequently injected into the thigh muscle. In the second group, physiologic saline was injected intramuscularly to determine the effects of cannulation and pressure on muscle tissue (6 rabbits). Fat autografts were performed on the right side of the animal, and the left side was used as the control. Scintigraphic imaging and histopathologic examination of the limbs were performed after injection of adipose tissue on days 15, 30, 45, 60, 90. and 120. On the technetium-99m (Tc-99m) hexamethylpropylene amine oxime scintigraphy, whereas similar activity distribution was observed between the left and right thigh on days 15, 30, and 45, there was increased uptake at the right thigh on days 60, 90, and 120. This increased uptake indicates that there is viable fat tissue in this region. Histopathologic evaluation showed that microcysts resulting from degeneration of some adipocytes and inflammatory changes on day 15 additionally increased vascularity and fibrosis in some animals on day 30, as well as fibrosis, microcysties, and focal calcification areas in adipose tissue on day 45 and later. It was observed that adipose tissue survived in more than 50% of the graft area in all the animals. These findings show that fat autografts can survive in muscle tissue with less than 50% fibrotic change.en_US
dc.identifier.doi10.1007/s00266-004-3121-7
dc.identifier.endpage339en_US
dc.identifier.issn0364-216X
dc.identifier.issue5en_US
dc.identifier.pmid15666051en_US
dc.identifier.scopus2-s2.0-13644267782en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage334en_US
dc.identifier.urihttps://doi.org/10.1007/s00266-004-3121-7
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21202
dc.identifier.volume28en_US
dc.identifier.wosWOS:000225864500015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAesthetic Plastic Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFree Fat Graften_US
dc.subjectMuscleen_US
dc.subjectRevascularizationen_US
dc.subjectScintigraphyen_US
dc.subjectSoft-Tissue Augmentationen_US
dc.subjectAdipose-Tissueen_US
dc.subjectAutologous Faten_US
dc.subjectLip Augmentationen_US
dc.subjectSurvivalen_US
dc.subjectTransplantationen_US
dc.subjectGraftsen_US
dc.subjectViabilityen_US
dc.titleThe fate of intramuscularly injected fat autografts: An experimental study in rabbitsen_US
dc.typeArticleen_US

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