Insulin resistance and high sensitivity C-reactive protein in migraine

Basit Öğe Kaydı
dc.authoridGULDIKEN, Baburhan/0000-0002-9006-1880
dc.contributor.authorGuldiken, Baburhan
dc.contributor.authorGuldiken, Sihel
dc.contributor.authorDemir, Muzaffer
dc.contributor.authorTurgut, Nilda
dc.contributor.authorKabayel, Levent
dc.contributor.authorOzkan, Hulya
dc.contributor.authorOzcelik, Emine
dc.date.accessioned2024-06-12T11:17:47Z
dc.date.available2024-06-12T11:17:47Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: A relationship between migraine and vascular disorders such as hypertension, stroke, and coronary ischemia has been recently reported. Insulin resistance and endothelial dysfunction. which commonly underlies these disorders, have not been widely investigated in migraine patients. In this study. we aimed to investigate the existence of insulin resistance and endothelial dysfunction, and their relationship to vascular risk factors in patients with migraine. Methods: We evaluated insulin resistance and high-sensitivity C-reactive protein (hs-CRP), a marker of endothelial dysfunction, in 60 migraine patients and 25 healthy control subjects. Multiple analysis of covariance test was used to adjust for known confounding factors that can influence insulin metabolism and endothelial Function, Such as obesity, blood pressure. and lipid parameters. Results: Insulin resistance, as measured homeostasis model assessment (HOMA)-R levels, was significantly higher in the migraine group (p < 0.001). After adjustment for confounding variables. the relationship between migraine and the HOMA-R levels remained significant (p < 0.001). The hs-CRP levels did not differ between the migraine and control groups. Conclusions: Our data show that insulin resistance is present in migraine patients. Endothelial dysfunction is not found during the headache-free period. Further studies are needed to explain the role of insulin resistance in migraine pathogenesis.en_US
dc.identifier.doi10.1017/S0317167100009100
dc.identifier.endpage451en_US
dc.identifier.issn0317-1671
dc.identifier.issn2057-0155
dc.identifier.issue4en_US
dc.identifier.pmid18973061en_US
dc.identifier.scopus2-s2.0-55049089972en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage448en_US
dc.identifier.urihttps://doi.org/10.1017/S0317167100009100
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24843
dc.identifier.volume35en_US
dc.identifier.wosWOS:000259650700007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofCanadian Journal Of Neurological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCardiovascular-Diseaseen_US
dc.subjectRisken_US
dc.subjectObesityen_US
dc.subjectAssociationen_US
dc.subjectGlucoseen_US
dc.subjectAuraen_US
dc.titleInsulin resistance and high sensitivity C-reactive protein in migraineen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu