The effect of the dipeptidyl peptidase-4 inhibitor sitagliptin on gentamicin nephrotoxicity in mice

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dc.authoridKARACA, Turan/0000-0002-2500-7781
dc.authoridNemmar, Abderrahim/0000-0002-0699-1015
dc.authoridAshique, Mohammed/0000-0002-3132-1478
dc.authorwosidKARACA, Turan/ABD-6669-2020
dc.contributor.authorAl Suleimani, Yousuf M.
dc.contributor.authorAbdelrahman, Aly M.
dc.contributor.authorKaraca, Turan
dc.contributor.authorManoj, Priyadarsini
dc.contributor.authorAshique, Mohammed
dc.contributor.authorNemmar, Abderrahim
dc.contributor.authorAli, Badreldin H.
dc.date.accessioned2024-06-12T11:02:35Z
dc.date.available2024-06-12T11:02:35Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThis study aimed at investigating the possible ameliorative effects of sitagliptin in mice with gentamicin (GEN) nephrotoxicity. Sitagliptin was given to the animals at an oral dose of 10 mg kg(-1) per day for 10 days, and in some of these mice, GEN was injected intraperitoneally at a dose of 100 mg kg(-1) per day during the last seven days of the treatment. Nephrotoxicity was evaluated histopathologically by light microscopy and biochemically by measuring several indices in plasma, urine and renal cortex homogenates. GEN treatment induced nephrotoxicity as evidenced by significantly (P < 0.0001) increasing the plasma concentrations of urea, creatinine, circulatory cytokines, cystatin C, sclerostin, and TNF alpha. Treatment with GEN also significantly elevated urinary N-acetyl-beta-D glucosaminidase (NAG) concentration (P < 0.0001). Moreover, GEN caused significant increase in oxidative stress in the kidneys (P < 0.0001). Histopathological examination revealed massive tubular injury, necrosis, infiltration of inflammatory cells and intraluminal hyaline casts in mice treated with GEN. Sitagliptin alone did not significantly affect any of the indices measured. However, concomitant treatment with sitagliptin and GEN significantly mitigated most of the nephrotoxic actions of GEN. Pending further studies, sitagliptin may potentially be useful as a nephroprotectant agent.en_US
dc.description.sponsorshipSultan Qaboos University, Oman [IG/MED/PHAR/17/1]en_US
dc.description.sponsorshipThis work was financially supported by a grant from Sultan Qaboos University, Oman (IG/MED/PHAR/17/1). The authors wish to thank Professor Gerald Blunden (University of Portsmouth, UK) for critically reading the manuscript.en_US
dc.identifier.doi10.1016/j.biopha.2017.10.107
dc.identifier.endpage1108en_US
dc.identifier.issn0753-3322
dc.identifier.issn1950-6007
dc.identifier.pmid29136947en_US
dc.identifier.scopus2-s2.0-85033402021en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1102en_US
dc.identifier.urihttps://doi.org/10.1016/j.biopha.2017.10.107
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21343
dc.identifier.volume97en_US
dc.identifier.wosWOS:000419041300132en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevieren_US
dc.relation.ispartofBiomedicine & Pharmacotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGentamicinen_US
dc.subjectNephrotoxicityen_US
dc.subjectNephroprotectionen_US
dc.subjectMiceen_US
dc.subjectSitagliptinen_US
dc.subjectAcute Kidney Injuryen_US
dc.subjectDpp-4 Inhibitorsen_US
dc.subjectAminoglycoside Nephrotoxicityen_US
dc.subjectDiseaseen_US
dc.subjectModelen_US
dc.subjectRatsen_US
dc.subjectDysfunctionen_US
dc.subjectMembraneen_US
dc.subjectProtectsen_US
dc.subjectTherapyen_US
dc.titleThe effect of the dipeptidyl peptidase-4 inhibitor sitagliptin on gentamicin nephrotoxicity in miceen_US
dc.typeArticleen_US

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