Genotoxic effects of diazinon on human peripheral blood lymphocytes

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dc.authoridKanev, Martin/0000-0001-8482-5074
dc.authoridGokalp, Fulya Dilek/0000-0001-8219-6657
dc.authorwosidKanev, Martin/C-5437-2016
dc.contributor.authorMuranli, Fulya Dilek Gokalp
dc.contributor.authorKanev, Martin
dc.contributor.authorOzdemir, Kezban
dc.date.accessioned2024-06-12T10:58:09Z
dc.date.available2024-06-12T10:58:09Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the genetic damage in human peripheral blood lymphocytes following 24 and 48-hour exposure to a commercial diazinon formulation Basudin 60EM (R) at concentrations between 0.01 and 40 mu g mL(-1). For this purpose we used the micronucleus (MN), fluorescence in situ hybridization (FISH), and alkaline single cell gel electrophoresis (comet) assay. Diazinon significantly increased the frequency of micronucleated cells compared to control. Forty-eight-hour exposure increased this frequency even at lower concentrations (0.01-10 mu g mL(-1)). The FISH results revealed aneugenic effects at 10 mu g mL(-1). The comet assay also confirmed DNA damage at concentrations between 10 and 40 mu g mL(-1). Our findings have confirmed the genotoxic potential of diazinon and its cytotoxic effect on human lymphocytes. The increased DNA damage in our study raises concern about the current assessment of the health risk posed by this pesticide and calls for a high level of caution in agricultural and household use.en_US
dc.identifier.doi10.1515/aiht-2015-66-2584
dc.identifier.endpage158en_US
dc.identifier.issn0004-1254
dc.identifier.issn1848-6312
dc.identifier.issue2en_US
dc.identifier.pmid26110477en_US
dc.identifier.scopus2-s2.0-84934753005en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage153en_US
dc.identifier.urihttps://doi.org/10.1515/aiht-2015-66-2584
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19960
dc.identifier.volume66en_US
dc.identifier.wosWOS:000358360900007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInst Medical Research & Occupational Healthen_US
dc.relation.ispartofArhiv Za Higijenu Rada I Toksikologiju-Archives Of Industrial Hygiene And Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectComet Assayen_US
dc.subjectFISHen_US
dc.subjectGenotoxicityen_US
dc.subjectMicronucleusen_US
dc.subjectOrganophosphate Pesticidesen_US
dc.subjectDna-Damageen_US
dc.subjectCellsen_US
dc.subjectAneuploidyen_US
dc.subjectExposureen_US
dc.subjectInductionen_US
dc.subjectWorkersen_US
dc.titleGenotoxic effects of diazinon on human peripheral blood lymphocytesen_US
dc.typeArticleen_US

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