Neuroserpin in Bipolar Disorder

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dc.contributor.authorCinar, Rugul Kose
dc.date.accessioned2024-06-12T10:54:43Z
dc.date.available2024-06-12T10:54:43Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Neuroserpin is a serine protease inhibitor predominantly expressed in the nervous system functioning mainly in neuronal migration and axonal growth. Neuroprotective effects of neuroseipin were shown in animal models of stroke, brain, and spinal cord injury. Postmortem studies confirmed the involvement of neuroserpin in Alzheimer's disease. Since altered adult neurogenesis was postulated as an aetiological mechanism for bipolar disorder, the possible effect of neuroserpin gene expression in the disorder was evaluated. Methods: Neuroserpin mRNA expression levels were examined in the peripheral blood of bipolar disorder type I manic and euthymic patients and healthy controls using the polymerase chain reaction method. The sample comprised of 60 physically healthy, middle-aged men as participants who had no substance use disorder. Results: The gene expression levels of neuroserpin were found lower in the bipolar disorder patients than the healthy controls (p=0.000). The neuroserpin levels did not differ between mania and euthymia (both 96% down-regulated compared to the controls). Conclusion: Since we detected differences between the patients and the controls, not the disease states, the dysregulation in the neuroserpin gene could be interpreted as a result of the disease itself.en_US
dc.description.sponsorshipPsychiatric Association of Turkey, Edirne subdivision [2016/01]en_US
dc.description.sponsorshipThe present work was sponsored by the Psychiatric Association of Turkey, Edirne subdivision (grant number 2016/01).en_US
dc.identifier.doi10.2174/1568026620666200131125526
dc.identifier.endpage523en_US
dc.identifier.issn1568-0266
dc.identifier.issn1873-5294
dc.identifier.issue7en_US
dc.identifier.pmid32003693en_US
dc.identifier.scopus2-s2.0-85084102579en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage518en_US
dc.identifier.urihttps://doi.org/10.2174/1568026620666200131125526
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19161
dc.identifier.volume20en_US
dc.identifier.wosWOS:000528283700003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofCurrent Topics In Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBipolar Disorderen_US
dc.subjectPeripheral Blooden_US
dc.subjectMrna Expressionen_US
dc.subjectNeuroserpinen_US
dc.subjectNeurogenesisen_US
dc.subjectNeuroprotectionen_US
dc.subjectPlasminogen-Activatoren_US
dc.subjectGene-Expressionen_US
dc.subjectProtease Inhibitoren_US
dc.subjectSchizophreniaen_US
dc.subjectDysregulationen_US
dc.subjectPrevalenceen_US
dc.subjectApoptosisen_US
dc.subjectBrainen_US
dc.subjectModelen_US
dc.titleNeuroserpin in Bipolar Disorderen_US
dc.typeArticleen_US

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