Assessment of cytokine levels and hs-CRP in bipolar I disorder before and after treatment

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dc.authoridGorgulu, Yasemin/0000-0002-3401-4879;
dc.authorwosidGorgulu, Yasemin/S-4355-2017
dc.authorwosidUyanik, Mehmet/AAD-7345-2020
dc.contributor.authorUyanik, Vesile
dc.contributor.authorTuglu, Cengiz
dc.contributor.authorGorgulu, Yasemin
dc.contributor.authorKunduracilar, Hakan
dc.contributor.authorUyanik, Mehmet Sevki
dc.date.accessioned2024-06-12T11:08:42Z
dc.date.available2024-06-12T11:08:42Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractWe aimed to assess the relationship between cytokine levels and the severity of the manic period in medication free patients. 30 Medication free patients and 28 healthy subjects (HS) were recruited. Plasma levels of pro-inflammatory, anti-inflammatory, inflammatory cytokines, and hs-CRP levels were investigated upon hospital admission, after six weeks follow up in bipolar disease manic episode and the results were compared to HS. The severity of the manic episodes was assessed according to the Young mania rating scale. TNF-alpha, INF-gamma, IL-6 and hs-CRP levels were significantly higher in patients with manic episode of bipolar I disorder before treatment than HS. After treatment the levels of TNF-alpha, INF-gamma, IL-6 and hs-CRP were observed to be significantly decreased. There was no difference between the levels of anti-inflammatory cytokines in patients before or after treatment of bipolar disorder and HS. hs-CRP was observed to be the only parameter correlated with clinical response. The most significant outcome of this study is the correlation between clinical outcome and hs-CRP levels in treatment naive manic episode bipolar type I patients. hs-CRP is the most consistent indicator according to pro-inflammatory, inflammatory and anti-inflammatory cytokines, in predicting treatment outcomes. (C) 2015 Elsevier Ireland Ltd. All rights reserved.en_US
dc.description.sponsorship'Trakya University Scientific Research Program' [TUTF-2009/021]en_US
dc.description.sponsorshipThe authors are grateful for the support of the 'Trakya University Scientific Research Program'. This work was supported by the 'Trakya University Scientific Research Program' (for all authors Grant no. TUTF-2009/021). All authors declare that they have no potential financial/non-financial conflict of interest.en_US
dc.identifier.doi10.1016/j.psychres.2015.05.078
dc.identifier.endpage392en_US
dc.identifier.issn0165-1781
dc.identifier.issue3en_US
dc.identifier.pmid26160203en_US
dc.identifier.scopus2-s2.0-84938738861en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage386en_US
dc.identifier.urihttps://doi.org/10.1016/j.psychres.2015.05.078
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22534
dc.identifier.volume228en_US
dc.identifier.wosWOS:000360251400023en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofPsychiatry Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMood Disorderen_US
dc.subjectManic Episodeen_US
dc.subjectInflammationen_US
dc.subjectAcute Phaseen_US
dc.subjectC-Reactive Proteinen_US
dc.subjectSerum-Levelsen_US
dc.subjectLithiumen_US
dc.subjectObesityen_US
dc.subjectImpacten_US
dc.subjectSchizophreniaen_US
dc.subjectInflammationen_US
dc.subjectActivationen_US
dc.subjectImbalanceen_US
dc.subjectSymptomsen_US
dc.titleAssessment of cytokine levels and hs-CRP in bipolar I disorder before and after treatmenten_US
dc.typeArticleen_US

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