Renal bcl-2/bax expression in childhood Henoch-Schonlein nephritis: prognostic importance?

Basit Öğe Kaydı
dc.authoridBulbul, Mehmet/0000-0002-4956-7548
dc.authoridBEK, KENAN/0000-0002-1005-2379
dc.authorwosidBulbul, Mehmet/AAM-7843-2021
dc.authorwosidBEK, KENAN/G-1418-2018
dc.contributor.authorBek, Kenan
dc.contributor.authorOksal, Aysegul
dc.contributor.authorDemircin, Gulay
dc.contributor.authorBulbul, Mehmet
dc.contributor.authorAydog, Ozlem
dc.contributor.authorDelibas, Ali
dc.contributor.authorOner, Ayse
dc.date.accessioned2024-06-12T10:52:20Z
dc.date.available2024-06-12T10:52:20Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAim: To investigate the renal expression of apoptosis regulatory proteins b-cell lymphoma 2 (bcl-2) and bcl-2 associated X (bax) in children with Henoch-Schonlein nephritis (HSN) Materials and methods: Renal expression of antiapoptotic bcl-2 and proapoptotic bax proteins were studied immunohistochemically in 22 children with HSN. The kidneys of 5 children who died due to nonrenal reasons were used as the control. The patients were compared according to their renal histopathology and prognosis. Results: Nephrotic or nephrotic-nephritic renal involvement was the most common presentation. Histopathological findings were Class I in 1, Class II in 5, Class III in 10, Class IV in 4, and Class V in 2 patients. IgA staining was shown in all biopsies. Bcl-2 and bax proteins mainly showed tubular and crescentic expression. This was significantly different for bcl-2 in tubules and bax in distal tubules compared to the controls (P < 0.05). No significant difference between bax and bcl-2 expression was observed among patients. However the mean values of the bcl-2/bax ratio, that is, the balance between survival and apoptosis, were significantly higher in crescents of the severe histopathologic group and in distal tubules of the poor prognosis group (P < 0.05). Conclusion: A higher bcl-2/bax ratio, that is relative to the predominance of cell survival in distal tubules and crescents in HSN, seems to be a poor prognostic factor in children.en_US
dc.identifier.doi10.3906/sag-1208-81
dc.identifier.endpage610en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue4en_US
dc.identifier.startpage606en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1208-81
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18679
dc.identifier.volume43en_US
dc.identifier.wosWOS:000323609800020en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApoptosisen_US
dc.subjectBaxen_US
dc.subjectBcl-2en_US
dc.subjectChildrenen_US
dc.subjectHenoch-Schonlein Nephritisen_US
dc.subjectPrognosisen_US
dc.subjectCell-Survivalen_US
dc.subjectApoptosisen_US
dc.subjectPurpuraen_US
dc.subjectGlomerulonephritisen_US
dc.subjectCaspase-3en_US
dc.subjectProteinsen_US
dc.subjectChildrenen_US
dc.subjectBaxen_US
dc.titleRenal bcl-2/bax expression in childhood Henoch-Schonlein nephritis: prognostic importance?en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu