The importance of serum total and lipid-bound sialic acid as markers in patients with small cell and non-small cell lung carcinoma

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dc.contributor.authorGokmen, Selma Suer
dc.contributor.authorKazezoglu, Cemal
dc.contributor.authorTabakoglu, Erhan
dc.contributor.authorAltiay, Guendeniz
dc.contributor.authorGungoer, Ozgul
dc.contributor.authorTure, Mevlut
dc.date.accessioned2024-06-12T11:14:15Z
dc.date.available2024-06-12T11:14:15Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description18th National Congress of Biochemistry -- MAY 15-19, 2004 -- Trabzon, TURKEYen_US
dc.description.abstractObjectives: Serum total sialic acid (TSA) and lipid-bound sialic acid (LSA) levels were investigated in patients with small and non-small cell lung carcinoma and their role in discriminating small from non-small cell lung carcinoma and lung carcinoma from healthy individuals was evaluated. Patients and Methods: The study included 159 male patients with non-small cell lung carcinoma (n=102) and small cell lung carcinoma (n=57) who never received chemotherapy and/or radiotherapy and 35 healthy volunteers as controls. Serum TSA and LSA levels were determined by the methods of Warren and Katopodis, respectively. Results: Serum TSA and LSA levels in both patient groups were significantly elevated when compared with controls (p < 0.001), but the patient groups did not differ significantly in this respect. Receiver operating characteristic (ROC) analysis showed that TSA was more specific and LSA was more sensitive in distinguishing patients with non-small cell carcinoma from healthy individuals. On the other hand, LSA was found to be more sensitive in distinguishing patients with small cell carcinoma from healthy controls. Conclusion: Serum total and lipid-bound sialic acid may play an important role as biochemical markers in distinguishing patients with small and non-small cell lung carcinoma from healthy subjects.en_US
dc.identifier.endpage108en_US
dc.identifier.issn1301-3149
dc.identifier.issue2en_US
dc.identifier.startpage101en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23865
dc.identifier.volume24en_US
dc.identifier.wosWOS:000257676900003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherAves Yayincilik, Ibrahim Karaen_US
dc.relation.ispartofTrakya Universitesi Tip Fakultesi Dergisien_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSmall Cell Lung Canceren_US
dc.subjectNon Small Cell Lung Canceren_US
dc.subjectTotal Sialic Aciden_US
dc.subjectLipid-Bound Sialic Aciden_US
dc.subjectMarkeren_US
dc.subjectTumor-Markersen_US
dc.subjectClinical-Significanceen_US
dc.subjectColorectal-Canceren_US
dc.subjectGrowthen_US
dc.subjectGlycoproteinen_US
dc.subjectMetabolismen_US
dc.titleThe importance of serum total and lipid-bound sialic acid as markers in patients with small cell and non-small cell lung carcinomaen_US
dc.typeConference Objecten_US

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