The comparison of intravenous patient controlled analgesia with meperidine or morphine for pain management after thoracotomy

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dc.authorscopusid6506587486
dc.authorscopusid55899471500
dc.authorscopusid18433550300
dc.authorscopusid38762072100
dc.authorscopusid39661007700
dc.authorscopusid7801349901
dc.authorscopusid6506413443
dc.contributor.authorSa?iro?lu G.
dc.contributor.authorGazi Kiraz O.
dc.contributor.authorBaysal A.
dc.contributor.authorSa?iro?lu T.
dc.contributor.authorÇopuro?lu E.
dc.contributor.authorMeydan B.
dc.contributor.authorYüksel V.
dc.date.accessioned2024-06-12T10:26:26Z
dc.date.available2024-06-12T10:26:26Z
dc.date.issued2013
dc.description.abstractObjective: To compare the effects of intravenous patient controlled analgesia(IV-PCA) with meperidine or morphine on hemodynamic parameters and pain control after thoracotomy operations. Methods: In this prospective study, 140 patients (ASA I-III) were randomly divided into meperidine (Group 1) and morphine (Group 2) groups. For IV-PCA in the postoperative first 24 hours, in Group I; a 50 mg loading dose, 7 mg hr-1 basal infusion, 5 mg demand dose, while, in Group II; a 5 mg loading dose, 0.5 mg hr-1 basal infusion, 0.5 mg demand dose was given,and the lock-out time was 15 minutes for both groups. The collected parameters included; systolic, diastolic, mean arterial blood pressures, heart rate, pulse-oximeter saturation, visual analog scala (VAS) and Ramsey sedation scale scores, total and additional analgesics amounts and side effects. Results: The VAS scores at 2, 4, 16. hours in Group 1 were significantly higher than in Group 2 (p=0.08; p=0.014; p=0.031). Within group analysis revealed decreased VAS scores in comparison to preoperative values in both groups (p=0.0001). Total and additional doses of morphine in Group 1 (calculated equivalent morphine dose depending on 25% incomplete cross tolerance) were higher than Group 2 (p=0.001, p=0.0001). Systolic, mean blood pressures at 2, 4, 8, 16 hours and diastolic blood pressures at 2, 4, 8 hours were higher in Group 1 when compared to Group 2 (p<0.05). The incidence of hypotension in Group 1 was 7.1%, being lower than Group 2 (18.6%; p=0.043). Conclusion: During post-thoracotomy pain therapy, IV-PCA with morphine provides more efficient analgesia than with meperidine. However, as hypotension is more commonly observed with morphine, its use is limited and requires a cautious approach.en_US
dc.identifier.doi10.5152/TJAR.2013.01
dc.identifier.endpage6en_US
dc.identifier.issn1304-0871
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84886310790en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.5152/TJAR.2013.01
dc.identifier.urihttps://hdl.handle.net/20.500.14551/16851
dc.identifier.volume41en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofTurk Anesteziyoloji ve Reanimasyon Dernegi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMeperidine; Morphine; Pain; Patient Controlled Analgesia; Thoracotomyen_US
dc.titleThe comparison of intravenous patient controlled analgesia with meperidine or morphine for pain management after thoracotomyen_US
dc.title.alternativeTorakotomi sonrasi{dotless} a?ri{dotless} tedavisinde meperidin veya morfin ile i?ntravenöz hasta kontrollü analjezi uygulamalari{dotless}ni{dotless}n karşi{dotless}laşti{dotless}ri{dotless}lmasi{dotless}en_US
dc.typeArticleen_US

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