Comparison of oral dolasetron and ondansetron in the prophylaxis of postoperative nausea and vomiting in children

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dc.contributor.authorKaramanlioglu, B
dc.contributor.authorTuran, A
dc.contributor.authorMemis, D
dc.contributor.authorSüt, N
dc.date.accessioned2024-06-12T10:51:57Z
dc.date.available2024-06-12T10:51:57Z
dc.date.issued2003
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground and objective: In a randomized, placebo-controlled, double-blind trial, we compared the efficacy of oral dolasetron and ondansetron in preventing postoperative nausea and vomiting in children after various surgical operations. Methods: Children were assigned randomly to one of three groups (each contained 50 children) to receive dolasetron 1.8 mg kg(-1) or ondansetron 0.15 mg kg(-1) orally, or a placebo. All children received methylene blue capsules (10 mg) orally as an indicator before the induction of anaesthesia. Postoperatively, contamination of the mouth and the endotracheal tube by methylene blue was recorded, and postoperative nausea and vomiting was recorded for 0-1, 1-24 and 0-24 h. Metoclopramide (0.1 mg kg(-1)) intravenously was used as the rescue antiemetic. Results: In the 0-1 h period after operation, there were no differences between the groups. In the 1-24 h period, dolasetron was significantly better than placebo (nausea 8 versus 24%; vomiting 4 versus 2096; total nausea and vomiting scores 16 versus 48176). Over the 0-24 h period, both dolasetron and ondansetron were significantly better than placebo (nausea 16 versus 26 versus 4096), vomiting (8 versus 16 versus 30%), and total nausea and vomiting scores (32 versus 48 versus 78%). There were no significant differences between dolasetron and ondansetron. There was no important methylene blue contamination, and little use of rescue metoclopramide. There were no important adverse events. Conclusions: Prophylactic oral dolasetron and ondansetron were effective in reducing postoperative nausea and vomiting in children.en_US
dc.identifier.doi10.1097/00003643-200310000-00010
dc.identifier.endpage835en_US
dc.identifier.issn0265-0215
dc.identifier.issn1365-2346
dc.identifier.issue10en_US
dc.identifier.pmid14580054en_US
dc.identifier.scopus2-s2.0-0141929552en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage831en_US
dc.identifier.urihttps://doi.org/10.1097/00003643-200310000-00010
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18549
dc.identifier.volume20en_US
dc.identifier.wosWOS:000186042700010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofEuropean Journal Of Anaesthesiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntiemetics, Dolasetron, Ondansetronen_US
dc.subjectComplications, Nausea, Retched, Vomitingen_US
dc.subjectPatients, Childrenen_US
dc.subjectPreventionen_US
dc.subjectHysterectomyen_US
dc.subjectDroperidolen_US
dc.subjectMetoclopramideen_US
dc.subjectCombinationen_US
dc.subjectAspirationen_US
dc.subjectAnesthesiaen_US
dc.subjectEfficacyen_US
dc.subjectSurgeryen_US
dc.titleComparison of oral dolasetron and ondansetron in the prophylaxis of postoperative nausea and vomiting in childrenen_US
dc.typeArticleen_US

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