The alteration of asymmetric dimetilarginine (ADMA) levels in cardiac and gastrocnemius muscles following radioactive iodine application in guinea pigs and the effect of L-carnitine on this alteration

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dc.authoridGunduz, Ozgur/0000-0002-2470-3021
dc.authoridTorun, Nese/0000-0002-5597-676X
dc.authoridKaya, Oktay/0000-0001-9639-8022
dc.authoridDURMUS ALTUN, GULAY/0000-0002-1822-9386
dc.authoridKaradag, Cetin Hakan/0000-0002-4763-986X
dc.authoridvardar, selma arzu/0000-0002-1073-1718
dc.authorwosidGunduz, Ozgur/A-2351-2016
dc.authorwosidTorun, Nese/AAE-2718-2021
dc.authorwosidKaya, Oktay/JGL-9169-2023
dc.authorwosidGÜNDÜZ, Özgür/AAH-8717-2019
dc.authorwosidDURMUS ALTUN, GULAY/S-6586-2016
dc.authorwosidAydogdu, Nurettin/ABH-9224-2020
dc.authorwosidKaradag, Cetin Hakan/H-4899-2013
dc.contributor.authorVardar, Selma Arzu
dc.contributor.authorGunduz, Ozgur
dc.contributor.authorAltun, Gulay Durmus
dc.contributor.authorAydogdu, Nurettin
dc.contributor.authorKaradag, Hakan
dc.contributor.authorTorun, Nese
dc.contributor.authorKaya, Oktay
dc.date.accessioned2024-06-12T10:52:44Z
dc.date.available2024-06-12T10:52:44Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose: Tissue levels of asymmetric dimetilarginine (ADMA) and symmetric dimetilarginine (SDMA) were investigated in cardiac ventricle and gastrocnemius muscles of guinea pigs treated with radioactive iodine (RAI) alone or in combination with L-carnitine (LC). Material and methods: Group 1 received no treatment (control group). Group 2 received a total dose of 30 mCi(-1)kg(-1) body weight iodine-131 alone. Group 3 received 200 mg(-1)kg(-1) of LC for 10 days alone. Group 4 received 200 mg(-1)kg(-1) of LC plus RAI therapy. Free thyroid hormones, ADMA and SDMA concentrations were measured. Results: Serum free thyroid hormone concentrations were found decreased in the RAI and LC-RAI groups after RAI application. A significant decrease in ADMA and SDMA concentration was observed in ventricle muscle following RAI application. The LC-RAI group had significantly decreased ADMA levels in ventricle muscle compared with those of the control group. Similarly, SDMA concentrations in ventricle and gastrocnemius muscles of the LC-RAI groups were significantly lower than those of the control groups. Conclusions: Our results indicated that RAI appears to exert an inhibitory effect on ADMA and SDMA levels of ventricular muscle. LC administration when given adjuvant to RAI therapy may cause a marked decrease in ADMA concentrations of both ventricular and gastrocnemius muscles.en_US
dc.identifier.doi10.3109/09553002.2010.518209
dc.identifier.endpage7en_US
dc.identifier.issn0955-3002
dc.identifier.issn1362-3095
dc.identifier.issue1en_US
dc.identifier.pmid20979544en_US
dc.identifier.scopus2-s2.0-78650102970en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2en_US
dc.identifier.urihttps://doi.org/10.3109/09553002.2010.518209
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18804
dc.identifier.volume87en_US
dc.identifier.wosWOS:000285144900002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal Of Radiation Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAsymmetric Dimethylarginineen_US
dc.subjectHypothyroidismen_US
dc.subjectMuscleen_US
dc.subjectRadioactive Iodineen_US
dc.subjectVentricleen_US
dc.subjectOxidative Stressen_US
dc.subjectCardiovascular Morbidityen_US
dc.subjectDimethylarginine Admaen_US
dc.subjectCancer-Mortalityen_US
dc.subjectVitamin-Een_US
dc.subjectRadiationen_US
dc.subjectAntioxidanten_US
dc.subjectPreventionen_US
dc.subjectArginineen_US
dc.subjectPlasmaen_US
dc.titleThe alteration of asymmetric dimetilarginine (ADMA) levels in cardiac and gastrocnemius muscles following radioactive iodine application in guinea pigs and the effect of L-carnitine on this alterationen_US
dc.typeArticleen_US

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