Relationship between cyclin D1 (A870G) gene polymorphism and lung cancer

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dc.authoridÖzen, Alaattin/0000-0001-9219-6001
dc.authoridÖzen, Alaattin/0000-0001-9219-6001
dc.authorwosidÖzen, Alaattin/IZQ-0388-2023
dc.authorwosidKocak, Zafer/AEG-7828-2022
dc.authorwosidÖzen, Alaattin/ABG-9988-2020
dc.contributor.authorCakina, Suat
dc.contributor.authorGulyasar, Tevfik
dc.contributor.authorOzen, Alaattin
dc.contributor.authorSipahi, Tammam
dc.contributor.authorKocak, Zafer
dc.contributor.authorSener, Seralp
dc.date.accessioned2024-06-12T11:07:53Z
dc.date.available2024-06-12T11:07:53Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe roles of many genes in the pathophysiology of lung cancer have been investigated in different studies. Cyclin D1 (CCND1) gene plays a significant role in the transition from G1 to S phase of the cell cycle and in the phosphorylation of retinoblastoma tumor suppressor protein. In this study, we aimed to identify the relationship between CCND1 A870G gene polymorphism with lung cancer. CCND1 A870G genotypes were determined in 75 patients with lung cancer and in 65 control subjects. DNA was isolated from blood samples and then CCND1 A870G gene polymorphism was identified using PCR and RFLP assay. The distribution of CCND1 A870G polymorphism did not show any significant differences in all lung cancer patients and controls. There was no correlation between CCND1 A870G polymorphism and histopathological findings. However, the AA + AG genotype was significantly higher in metastatic patients, when compared with non-metastatic patients. Thus, the results show that CCND1 gene polymorphism may be a predictor for detecting patients with poor survival who having metastatic disease.en_US
dc.description.sponsorshipTrakya University Scientific Research Projects Unit [TUBAP-893]en_US
dc.description.sponsorshipThe authors thank the Trakya University Scientific Research Projects Unit for funding of this project in part (No. TUBAP-893).en_US
dc.identifier.endpage236en_US
dc.identifier.issn0301-1208
dc.identifier.issn0975-0959
dc.identifier.issue3en_US
dc.identifier.pmid23898488en_US
dc.identifier.scopus2-s2.0-84924265175en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage233en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22219
dc.identifier.volume50en_US
dc.identifier.wosWOS:000321541000010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNatl Inst Science Communication-Niscairen_US
dc.relation.ispartofIndian Journal Of Biochemistry & Biophysicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLung Canceren_US
dc.subjectCyclin D1en_US
dc.subjectGene Polymorphismen_US
dc.subjectOverexpressionen_US
dc.subjectAmplificationen_US
dc.titleRelationship between cyclin D1 (A870G) gene polymorphism and lung canceren_US
dc.typeArticleen_US

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