Midkine Levels and its Relationship with Atherosclerotic Risk Factors in Essential Hypertensive Patients

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dc.authoridAydemir, Birsen/0000-0003-1406-864X
dc.authoridçavuşoğlu, coşkun/0000-0001-9238-3878
dc.authorwosidCinemre, Hakan/AAD-7506-2021
dc.authorwosidAydemir, Birsen/HKO-5522-2023
dc.authorwosidCavusoglu, Coskun/AAD-4119-2019
dc.authorwosidçavuşoğlu, coşkun/JXM-7806-2024
dc.contributor.authorGuzel, S.
dc.contributor.authorCinemre, F. B. S.
dc.contributor.authorGuzel, E. C.
dc.contributor.authorKucukyalcin, V.
dc.contributor.authorKiziler, A. R.
dc.contributor.authorCavusoglu, C.
dc.contributor.authorGulyasar, T.
dc.date.accessioned2024-06-12T10:52:45Z
dc.date.available2024-06-12T10:52:45Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground and Objectives: Hypertension (HT) is one of the risk factors associated with atherosclerosis. Midkine (MK) plays a role as a growth factor in various biologic and pathologic events. In some reports, MK expression has been shown to be linked with vascular smooth muscle proliferation and neo-angiogenesis in atherosclerotic vessels. The aim was to research relationship of MK serum levels with some atherosclerotic risk factors in hypertensive patients. Methodology: This study examined 60 patients with essential HT and 30 healthy controls. Serum biochemistry, including lipid profile, MK, Vitamin B 12, C-reactive protein, zinc and copper levels were obtained. Results: MK levels of the HT patients were significantly higher than the control group (24.8 +/- 6.8 ng/mL vs. 18.39 +/- 5.6 ng/mL, respectively, P < 0.01). Lipid profile parameters such as total cholesterol, triglyceride, low-density lipoprotein (LDL) were also significantly higher in HT patients (P < 0.021, P < 0.01, and P < 0.01, respectively). Zinc levels were 179.13 +/- 34.06 mu g/dL and 172.55 +/- 45.47 mu g/dL in the HT and control group, respectively. Serum MK levels were positively correlated with diastolic (r = 0.288, P < 0.05) and systolic blood pressures (r = 0.390, P < 0.002), and also with serum total cholesterol (r = 0.406, P < 0.002) and LDL cholesterol (r = 0.318, P < 0.015) levels. Furthermore MK was also negatively correlated with zinc and Vitamin B 12 levels (r = -0.298, P < 0.023, r = -0.334, P < 0.027, respectively). Conclusion: This study has demonstrated an important association between increased serum MK levels and risk factors of atherosclerosis such as HT, increased total and LDL cholesterol.en_US
dc.identifier.doi10.4103/njcp.njcp_309_17
dc.identifier.endpage900en_US
dc.identifier.issn1119-3077
dc.identifier.issue7en_US
dc.identifier.pmid29984722en_US
dc.identifier.scopus2-s2.0-85050107987en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage894en_US
dc.identifier.urihttps://doi.org/10.4103/njcp.njcp_309_17
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18821
dc.identifier.volume21en_US
dc.identifier.wosWOS:000439047000013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofNigerian Journal Of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAtherosclerosisen_US
dc.subjectCholesterolen_US
dc.subjectHypertensionen_US
dc.subjectMidkineen_US
dc.subjectBinding Growth-Factoren_US
dc.subjectExperimental Autoimmune Encephalomyelitisen_US
dc.subjectZinc-Deficiencyen_US
dc.subjectBiological-Activitiesen_US
dc.subjectDiabetic-Nephropathyen_US
dc.subjectKidney-Diseasesen_US
dc.subjectInflammationen_US
dc.subjectPleiotrophinen_US
dc.subjectPathogenesisen_US
dc.subjectAngiotensinen_US
dc.titleMidkine Levels and its Relationship with Atherosclerotic Risk Factors in Essential Hypertensive Patientsen_US
dc.typeArticleen_US

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