INDUCTION OF MICRONUCLEI IN MICE BONE MARROW CELLS BY COBALT AND COPPER CHLORIDES

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dc.authoridgoc rasgele, pınar/0000-0002-7558-3138
dc.authoridGokalp, Fulya Dilek/0000-0001-8219-6657
dc.authorwosidgoc rasgele, pınar/S-8923-2016
dc.contributor.authorRasgele, Pinar Goc
dc.contributor.authorKekecoglu, Meral
dc.contributor.authorMuranli, Fulya Dilek Gokalp
dc.date.accessioned2024-06-12T10:58:02Z
dc.date.available2024-06-12T10:58:02Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of our research was to investigate the genotoxic effects of cobalt chloride and copper chloride in mouse bone marrow cells using the micronucleus (MN) assay. The three different concentrations of cobalt chloride (11.2, 22.5 and 45 mg kg(-1)) and copper chloride (1.17, 2.35 and 4.70 mg kg(-1)) were injected intraperitoneally to mice for 24 and 48 hours. It was observed that both of these heavy metals induced a significant increase in frequency of micronucleated polychromatic erythrocytes (MNPCE) at different concentrations in mice for 24 and 48 hours when compared with the control. Furthermore, the significant reduction for the polychromatic erythrocyte/normochromatic erythrocyte (PCE/NCE) ratio which is indicative of bone marrow cytotoxicity was observed in bone marrow cells which were treated with copper chloride at all concentrations for 24 and 48 hours. No reduction of the PCE/NCE ratio was observed both 24 and 48 hours after all the doses of cobalt chloride tested as compared to the negative control. These results lead us to the conclusion that copper chloride may have genotoxic and cytotoxic properties due to induction in the frequency of MN and a reduction in PCE/NCE ratio in bone marrow cells of mice, whereas cobalt chloride induced only genotoxic effect in mice bone marrow.en_US
dc.identifier.doi10.2478/aep-2013-0007
dc.identifier.endpage82en_US
dc.identifier.issn2083-4772
dc.identifier.issn2083-4810
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84880023719en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage75en_US
dc.identifier.urihttps://doi.org/10.2478/aep-2013-0007
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19903
dc.identifier.volume39en_US
dc.identifier.wosWOS:000316162100007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPolska Akad Nauk, Polish Acad Sciences, Inst Environ Eng Pasen_US
dc.relation.ispartofArchives Of Environmental Protectionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCobalt Chlorideen_US
dc.subjectCopper Chlorideen_US
dc.subjectHeavy Metalen_US
dc.subjectMiceen_US
dc.subjectMicronucleus Assayen_US
dc.subjectIn-Vivoen_US
dc.subjectMetal-Compoundsen_US
dc.subjectHeavy-Metalsen_US
dc.subjectSulfateen_US
dc.subjectMutagenicityen_US
dc.subjectGenotoxicityen_US
dc.subjectDerivativesen_US
dc.subjectProtectionen_US
dc.subjectExposureen_US
dc.subjectMutationen_US
dc.titleINDUCTION OF MICRONUCLEI IN MICE BONE MARROW CELLS BY COBALT AND COPPER CHLORIDESen_US
dc.typeArticleen_US

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