Importance of Neutrophil Gelatinase-Associated Lipocalin in Differential Diagnosis of Acute and Chronic Renal Failure

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dc.authoridOzkan, Seda/0000-0003-1835-8820
dc.authoridkavalcı, cemil/0000-0003-2529-2946
dc.authoridIpekci, Afsin/0000-0001-6125-4061
dc.authorwosidOzkan, Seda/AAE-8598-2019
dc.authorwosidkavalcı, cemil/AGG-1308-2022
dc.authorwosidIpekci, Afsin/E-3443-2017
dc.contributor.authorOzkan, Seda
dc.contributor.authorDurukan, Polat
dc.contributor.authorKavalci, Cemil
dc.contributor.authorDuman, Ali
dc.contributor.authorSayhan, Mustafa Burak
dc.contributor.authorSalt, Omer
dc.contributor.authorIpekci, Afsin
dc.date.accessioned2024-06-12T11:13:36Z
dc.date.available2024-06-12T11:13:36Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Neutrophil Gelatinase-associated Lipocalin (NGAL) protein is easily detected in the blood and urine soon after acute renal injury NGAL gains features of an early, sensitive and noninvasive biomarker for acute renal injury Recent evidences suggest that its expression is also increased in CRF reflecting the severity of disease. Objectives: In the present study, we aimed to investigate whether blood NGAL level plays a role in the differential diagnosis of acute and chronic renal failure. Patients and Methods: This was a prospective case-control study. Fifty patients presented to emergency department with acute renal failure (ARF), 30 with chronic renal failure (CRF) and 20 healthy individuals as control group were included in this study Blood pH, HCO3(-), BUN, creatinine and potassium values were evaluated in all patients. Blood NGAL values were evaluated in all groups. BUN, serum creatinine and NGAL values were statistically compared between patients and controls. Results: Median NGAL levels in patients was 304.50 (29), and 60 (0) in control, which was statistically significant between the two groups (Z = -6.477, P < 0.001). The median NGAL values were 261.50 +/- 291 in ARF group and 428.50 +/- 294 in CRF group. There was a significant difference in NGAL level between ARF and CRF groups (Z = -2.52, P = 0.012). Median BUN values were 153.46 +/- 82.47 in ARE group and 169.40 +/- 93.94 in CRF group. There was no significant difference in BUN value between ARF and CRF groups (P > 0.05). Median creatinine values were 2.84 +/- 2.95 in ARF group and 4.78 +/- 4.32 in CRF group. In serum creatinine values, a significant difference was found between ARF and CRE groups (P <0.05). Conclusions: Serum NGAL levels of ARE and CRF patients were significantly higher than healthy individuals. In addition, NGAL values of patients with CRF were significantly higher than those of ARE. Serum NGAL values can be used to detect renal injury and differentiate ARE and CREen_US
dc.identifier.doi10.5812/ircmj.14133
dc.identifier.issn2074-1804
dc.identifier.issn2074-1812
dc.identifier.issue8en_US
dc.identifier.pmid25389480en_US
dc.identifier.scopus2-s2.0-84982227921en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.5812/ircmj.14133
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23589
dc.identifier.volume16en_US
dc.identifier.wosWOS:000347166700015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKowsar Publen_US
dc.relation.ispartofIranian Red Crescent Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRenal Failureen_US
dc.subjectChronicen_US
dc.subjectAcuteen_US
dc.subjectNGAL Proteinen_US
dc.subjectAcute Kidney Injuryen_US
dc.subjectCardiac-Surgeryen_US
dc.subjectNgalen_US
dc.titleImportance of Neutrophil Gelatinase-Associated Lipocalin in Differential Diagnosis of Acute and Chronic Renal Failureen_US
dc.typeArticleen_US

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