Comparison of sufentanil with sufentanil plus magnesium sulphate for sedation in the intensive care unit using bispectral index

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dc.contributor.authorMemis, D
dc.contributor.authorTuran, A
dc.contributor.authorKaramanlioglu, B
dc.contributor.authorOguzhan, N
dc.contributor.authorPamukçu, Z
dc.date.accessioned2024-06-12T10:54:45Z
dc.date.available2024-06-12T10:54:45Z
dc.date.issued2003
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIntroduction In intensive care unit patients we assessed, using bispectral index (BIS) monitoring, whether the addition of magnesium sulphate infusion could decrease the sufentanil infusion required to maintain sedation. Patients and methods A total of 30 adult patients who were expected to require mechanical ventilation for 6 hours in the intensive care unit were randomly assigned to receive either sufentanil infusion or sufentanil plus magnesium infusion. We monitored BIS levels continously. BIS levels in the range 61-88 are required to maintain a state of sedation, and in both groups BIS levels were kept within this range by increasing or decreasing the sufentanil infusion. Hourly consumption of sufentanil was monitored. Cardiovascular, respiratory and biochemical data were recorded. Results There was no significant difference between the groups with respect to cardiovascular, respiratory and biochemical parameters. Magnesium infusion, when added to sufentanil infusion, decreased the consumption of sufentanil at all times accept during the first hour (P < 0.001). There was no significant difference in BIS values between the groups (P > 0.05). Conclusion This is the first clinical study to demonstrate that magnesium sulphate infusion decreases sufentanil requirements. Because of the limited number of patients included and the short period of observation, our findings must be confirmed by larger clinical trials of magnesium infusion titrated to achieve prespecified levels of sedation. Furthermore, randomized clinical studies are needed to determine the effects of magnesium infusion on opioids.en_US
dc.identifier.doi10.1186/cc2365
dc.identifier.endpageR128en_US
dc.identifier.issn1466-609X
dc.identifier.issn1364-8535
dc.identifier.issue5en_US
dc.identifier.pmid12974980en_US
dc.identifier.scopus2-s2.0-84991255235en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpageR123en_US
dc.identifier.urihttps://doi.org/10.1186/cc2365
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19168
dc.identifier.volume7en_US
dc.identifier.wosWOS:000185317500008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofCritical Careen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBispectral Indexen_US
dc.subjectIntensive Care Uniten_US
dc.subjectMagnesiumen_US
dc.subjectSedationen_US
dc.subjectSufentanilen_US
dc.subjectLong-Term Sedationen_US
dc.subjectMechanical Ventilationen_US
dc.subjectMidazolamen_US
dc.subjectPropofolen_US
dc.subjectPatienten_US
dc.subjectDepthen_US
dc.titleComparison of sufentanil with sufentanil plus magnesium sulphate for sedation in the intensive care unit using bispectral indexen_US
dc.typeArticleen_US

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