POTENTIAL GENOTOXICITY OF ACETAMIPRID AND PROPINEB SINGLY OR IN COMBINATION IN CULTURED HUMAN PERIPHERAL BLOOD LYMPHOCYTES BY USING MN ASSAY

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dc.authoridgoc rasgele, pınar/0000-0002-7558-3138
dc.authoridGokalp, Fulya Dilek/0000-0001-8219-6657
dc.authorwosidgoc rasgele, pınar/S-8923-2016
dc.contributor.authorMuranli, Fulya Dilek Gokalp
dc.contributor.authorRasgele, Pinar Goc
dc.contributor.authorKekecoglu, Meral
dc.contributor.authorKanev, Martin
dc.contributor.authorOzdemir, Kezban
dc.date.accessioned2024-06-12T10:50:19Z
dc.date.available2024-06-12T10:50:19Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAcetamiprid, a neonicotinoid insecticide, and Propineb, a dithicarbamate fungicide, are used in agriculture singly or in combination with other pesticides. The aim of the study is to investigate the single and combined genotoxic effect two pesticides on cultured human lymphocytes by using the Micronucleus (MN) assay. The lymphocytes were treated with three different concentrations of pesticides singly and in combination (a mix), Acetamiprid (0.625, 1.25, 2.5 mu g mL(-1)) Propineb (12.5, 25, 50 mu g mL(-1)) and Acetamiprid+Propineb (0.625+12.5, 1.25+25, 2.5+50 mu g mL(-1)), for 24 and 48 hours. MN frequency significantly increased at a 48-hour exposure period when the lymphocytes were exposed to the combined pesticides. The data demonstrated that these pesticides may have a synergistic effect and may have potential genotoxic activity in cultured human lymphocytes. Also, it was shown that when they are combined and exposed to lymphocytes these pesticides have a cytotoxic effect.en_US
dc.description.sponsorshipDuzce University DUBAP project [2011.05.01.070]en_US
dc.description.sponsorshipThis work was supported by grants from the Duzce University DUBAP project 2011.05.01.070.en_US
dc.identifier.endpage3955en_US
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue11Ben_US
dc.identifier.startpage3947en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17967
dc.identifier.volume24en_US
dc.identifier.wosWOS:000367698600008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherParlar Scientific Publications (P S P)en_US
dc.relation.ispartofFresenius Environmental Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcetamipriden_US
dc.subjectPropineben_US
dc.subjectIn Vitroen_US
dc.subjectHuman Lymphocyte Cultureen_US
dc.subjectDithiocarbamate Fungicide Propineben_US
dc.subjectIn-Vitroen_US
dc.subjectOxidative Stressen_US
dc.subjectPesticide Mixturesen_US
dc.subjectOchratoxin-Aen_US
dc.subjectMicronucleusen_US
dc.subjectGlutathioneen_US
dc.subjectToxicityen_US
dc.subjectCypermethrinen_US
dc.subjectCellsen_US
dc.titlePOTENTIAL GENOTOXICITY OF ACETAMIPRID AND PROPINEB SINGLY OR IN COMBINATION IN CULTURED HUMAN PERIPHERAL BLOOD LYMPHOCYTES BY USING MN ASSAYen_US
dc.typeArticleen_US

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