The Effect of Glutathione Treatment on the Biochemical and Immunohistochemical Profile in Streptozotocin-Induced Diabetic Rats

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dc.authoridKARACA, Turan/0000-0002-2500-7781
dc.authoridOzdemir, Hulya/0000-0002-6045-8342
dc.authoridDede, Semiha/0000-0001-5744-6327
dc.authorwosidDede, Semiha/H-5403-2013
dc.authorwosidKARACA, Turan/ABD-6669-2020
dc.contributor.authorYur, Fatmagul
dc.contributor.authorDede, Semiha
dc.contributor.authorKaraca, Turan
dc.contributor.authorYegin, Sevim Ciftci
dc.contributor.authorDeger, Yeter
dc.contributor.authorOzdemir, Hulya
dc.date.accessioned2024-06-12T10:54:36Z
dc.date.available2024-06-12T10:54:36Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThis study investigated the possible role of glutathione (GSH) in diabetic complications and its biochemical safety in experimental diabetic rats. Serum biochemical parameters and the histology of the pancreas were investigated. Seven rats were separated as controls. To create the diabetes in rats, 45 mg/kg single-dose streptozotocin (STZ) was administered i.p. The treatment was continued for 1 month. STZ was administered to the diabetes + GSH group, then reduced GSH, dissolved in isotonic salt solution (200 mg/kg), was applied i.p. two times a week. The GSH group received i.p. GSH. Serum biochemical parameters were determined by autoanalyzer. Immunohistochemical procedures were used to determine the percentage of the insulin-immunoreactive beta-cell area in the islets of Langerhans. The biochemical parameters changed to different degrees or did not change. Pancreatic cells of the control and GSH groups were healthy, but in the diabetic and GSH-treated diabetic groups we found damage in different numbers. The results from these analyses show that GSH supplementation can exert beneficial effects on pancreatic cells in STZ-induced diabetic rats and can safely be used for therapy in and protection from diabetes and complications of diabetes.en_US
dc.identifier.doi10.1007/s00232-013-9541-z
dc.identifier.endpage433en_US
dc.identifier.issn0022-2631
dc.identifier.issn1432-1424
dc.identifier.issue6en_US
dc.identifier.pmid23681352en_US
dc.identifier.scopus2-s2.0-84879412968en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage427en_US
dc.identifier.urihttps://doi.org/10.1007/s00232-013-9541-z
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19097
dc.identifier.volume246en_US
dc.identifier.wosWOS:000320403100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Membrane Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiochemical Parameteren_US
dc.subjectDiabetesen_US
dc.subjectGlutathioneen_US
dc.subjectImmunohistochemistryen_US
dc.subjectRaten_US
dc.subjectOxidative Stressen_US
dc.subjectOral Glutathioneen_US
dc.subjectSerum Amylaseen_US
dc.subjectInsulinen_US
dc.subjectGlucoseen_US
dc.subjectNephropathyen_US
dc.subjectDysfunctionen_US
dc.subjectMelatoninen_US
dc.subjectMellitusen_US
dc.subjectLipaseen_US
dc.titleThe Effect of Glutathione Treatment on the Biochemical and Immunohistochemical Profile in Streptozotocin-Induced Diabetic Ratsen_US
dc.typeArticleen_US

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