The effects of long-term low-dose cyclosporin A treatment on muscles and tendons: an experimental study

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dc.authoridAktas, Ranan/0000-0002-4474-7371
dc.authorwosidAktas, Ranan/F-2910-2016
dc.contributor.authorAktas, Ranan Guelhan
dc.contributor.authorAktas, Seref
dc.contributor.authorYazgan, Oemer
dc.contributor.authorAltaner, Semsi
dc.date.accessioned2024-06-12T10:59:06Z
dc.date.available2024-06-12T10:59:06Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBACKGROUND Limited studies report that patients receiving immunosuppressive therapy, including cyclosporin A (CsA), face muscle and/or tendon pathologies. The current study aimed (i) to investigate if CsA cause changes in the microscopic structure of striated muscle tissues and tendons after long-term low-dose therapy and (ii) to examine if the vehicle of CsA, Cremophor EL, or steroid administration might cause additional effects. METHODS Twenty-four adult female Sprague-Dawley rats weighing 230300 g were divided at random into four groups. Group 1 served as the control. Groups 2-4 received CsA intraperitoneally for 2.5 months: Group 2 received the oral form of CsA, Group 3 received the intravenous form of CsA, which contains Cremophor EL, and Group 4 received the intravenous form of CsA and prednisolone. Samples from the Achilles tendons and triceps surae muscles were examined at light microscope level. RESULTS Focal necrotic areas, enlargement of connective tissue and increase in mononuclear cells were clear on muscles in the experimental groups. No morphologic effects were observed on tendons. CONCLUSION Long-term low-dose CsA therapy causes focal microscopic changes in muscles but not in tendons. No additional effects were demonstrated with Cremophor EL or steroids. It should be noted that muscle tissue damage after trauma or surgeries in patients receiving CsA might be more dramatic due to the pathologic changes already caused by CsA, as supported by several case reports.en_US
dc.identifier.endpage323en_US
dc.identifier.issn1306-696X
dc.identifier.issue4en_US
dc.identifier.pmid19669958en_US
dc.identifier.scopus2-s2.0-68049090910en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage317en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20305
dc.identifier.volume15en_US
dc.identifier.wosWOS:000267861900003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Assoc Trauma Emergency Surgeryen_US
dc.relation.ispartofUlusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal Of Trauma & Emergency Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCyclosporin Aen_US
dc.subjectLight Microscopeen_US
dc.subjectMuscleen_US
dc.subjectTendonen_US
dc.subjectSoleus Muscleen_US
dc.subjectAchilles Tendinopathyen_US
dc.subjectAssociationen_US
dc.subjectMassen_US
dc.titleThe effects of long-term low-dose cyclosporin A treatment on muscles and tendons: an experimental studyen_US
dc.typeArticleen_US

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