Synthesis of pincer type carbene and their Ag(I)-NHC complexes, and their antimicrobial activities

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dc.authorscopusid6507892320
dc.authorscopusid58155544000
dc.authorscopusid9735216100
dc.contributor.authorTürkyilmaz M.
dc.contributor.authorDönmez M.
dc.contributor.authorAteş M.
dc.date.accessioned2024-06-12T10:26:24Z
dc.date.available2024-06-12T10:26:24Z
dc.date.issued2022
dc.description.abstractIn this study, theophylline (1) compounds were synthesized with addition of 2-bromoetha-nol, 2-bromoacetamide and methyl-2-bromoacetate to attain symmetric connections to NHCs (2a–c). New complexes containing the symmetric N-heterocyclic carbene (NHC) ligands were synthesized using azolium salts in dimethyl formamide (DMF). After the NHC predecessor compounds reacted with Ag2 O, Ag(I)-NHC complexes were synthesized in the following: 7,9-di-(2-hydroxyethyl)-8,9-dihydro-1,3-dimethyl-1H-purine-2,6(3H,7H)-dionedium sil-ver(I)bromide (3a), 7,9-di(acetamide)-8,9-dihydro-1,3-dimethyl-1H-purine-2,6(3H,7H)-di-ondium silver(I)bromide (3b) and 7,9-di(methylacetate)-8,9-dihydro-1,3-dimethyl-1H-pu-rine-2,6(3H,7H)-diondiumsilver(I)bromide (3c). Both synthesized NHC predecessors (2a-c) and Ag(I)-NHC complexes (3a-c) were described by FTIR,1H-NMR,13C-NMR, liquid and solid-state conductivity values, TGA analysis, melting point analysis and XRD spectroscopy. In-vitro antibacterial activities of NHC-predecessors and Ag(I)-NHC complexes were tested against gram-positive bacteria (Staphylococcus Aureus and Bacillus Cereus), gram-negative bacteria (Escherichia Coli and Listeria Monocytogenes), and fungus (Candida Albicans) in Tryptic Soy Broth method. Ag(I)-NHC complexes showed higher antibacterial activity than pure NHC predecessors. The lowest microbial inhibition concentration (MIC) value of com-pound 3a was obtained as 11.56 ?g/ml for Escherichia Coli and 11.52 ?g/ml for Staphylococcus Aureus. All tested complexes displayed antimicrobial activity with different results. © 2022, Kare Publishing. All rights reserved.en_US
dc.description.sponsorshipThe authors confirm that the data that supports the findings of this study are available within the article. Raw data that support the finding of this study are available from the corresponding author, upon reasonable request. CONFLICT OF INTEREST The authors declare that they have no conflict of interest. FINANCIAL DISCLOSURE The research grant (TUBAP-2014-106) from Trakya University Research Fund is gratefully acknowledged. PEER-REVIEW Externally peer-reviewed.en_US
dc.identifier.doi10.47481/jscmt.1117139
dc.identifier.endpage61en_US
dc.identifier.issn2458-973X
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85138697454en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage53en_US
dc.identifier.trdizinid533168en_US
dc.identifier.urihttps://doi.org/10.47481/jscmt.1117139
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/533168
dc.identifier.urihttps://hdl.handle.net/20.500.14551/16830
dc.identifier.volume7en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherKare Publishingen_US
dc.relation.ispartofJournal of Sustainable Construction Materials and Technologiesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntimicrobial Activity; Candida Albicans; N-Heterocyclic Carbene (Nhcs); Sem Analysis; Theophyllineen_US
dc.titleSynthesis of pincer type carbene and their Ag(I)-NHC complexes, and their antimicrobial activitiesen_US
dc.typeArticleen_US

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