Short term effects of GnRH agonists on plasma fibrinolytic balance in patients with advanced prostate cancer
Küçük Resim Yok
Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background Gonadotropin releasing hormone (GnRH) agonists are the cornerstone of metastatic prostate cancer treatment. Cardiovascular effects of GnRH agonists are unclear. In this study, we investigated the short term effects of GnRH agonists on plasma fibrinolytic parameters in patients with metastatic prostate cancer. Methods Eleven patients (mean age 69.3 +/- A 6.5) with metastatic prostate cancer and a clinical indication for GnRH agonist therapy were selected. Plasma plasminogen activator inhibitor (PAI-1) antigen (Ag), tissue plasminogen activator (t-PA) Ag and thrombin-activatable fibrinolysis inhibitor (TAFI) activity levels were measured at baseline and at 4 weeks after the first dose of GnRH agonist, Goserelin Acetate (Zoladex(A (R)), subcutaneous administration, 10.8 mg). Results Serum prostate specific antigen (PSA) levels significantly decreased from 36.6 +/- A 19.3 to 1.1 +/- A 0.3 ng/ml after Goserelin acetate treatment (P = 0.005). Significant changes occurred in the fibrinolytic parameters. GnRH agonists decreased plasma t-PA Ag levels (16.3 +/- A 4.9 vs. 12.2 +/- A 2.8 ng/ml, P = 0.047) and increased PAI-1/t-PA molar ratio (4.8 +/- A 3.6 vs. 6.6 +/- A 3.4, P = 0.16), on the other hand, plasma PAI-1 Ag (59.0 +/- A 48.5 vs. 56.4 +/- A 30.5 ng/ml, P = 0.8), and TAFI levels (130.6 +/- A 9.5 vs. 124.2 +/- A 26.5% activity, P = 0.3) did not change significantly. Conclusion This study provides evidence that GnRH agonists may inhibit fibrinolytic system by decreasing t-PA levels.
Açıklama
Anahtar Kelimeler
Testosterone, Gnrh Agonists, Plasma Fibrinolytic Balance, PAI-1, T-PA, TAFI, Tissue-Plasminogen-Activator, Endothelial-Cells, Testosterone, Disease, Risk
Kaynak
Journal Of Thrombosis And Thrombolysis
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
27
Sayı
2
