A biomarker and therapeutical target in immune thrombocytopenia: TNF receptor-associated factor 6

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dc.contributor.authorAsoglu, Veysi
dc.contributor.authorUmit, Elif G.
dc.contributor.authorDemir, Muzaffer
dc.date.accessioned2024-06-12T11:07:08Z
dc.date.available2024-06-12T11:07:08Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Immune thrombocytopenia (ITP) is an acquired disease characterized by various pathogenetic mechanisms. We aimed to evaluate the value of TRAF6 as a biomarker of pathogenesis in ITP. Methods:85 newly diagnosed ITP patients and 85 controls were included. Results: In the patient group, mean TRAF6 level was 2348pg/ml and in the control group, TRAF6 level was 25.57pg/ml. In corticosteroid-responding patients, TRAF6 levels were lower than nonresponding patients. Discussion: TRAF6 levels were observed to be higher than healthy controls, which suggest a solid relation with ITP pathogenesis. The observation that in patients who present with high TRAF6 levels, there was a significant corticosteroid refractoriness and responsiveness.en_US
dc.identifier.doi10.2217/bmm-2018-0236
dc.identifier.endpage31en_US
dc.identifier.issn1752-0363
dc.identifier.issn1752-0371
dc.identifier.issue1en_US
dc.identifier.pmid30556735en_US
dc.identifier.scopus2-s2.0-85060035734en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage27en_US
dc.identifier.urihttps://doi.org/10.2217/bmm-2018-0236
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21918
dc.identifier.volume13en_US
dc.identifier.wosWOS:000458331700004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherFuture Medicine Ltden_US
dc.relation.ispartofBiomarkers In Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectImmune Thrombocytopeniaen_US
dc.subjectImmunityen_US
dc.subjectTRAF6en_US
dc.subjectPurpuraen_US
dc.subjectPathophysiologyen_US
dc.subjectAutoantibodiesen_US
dc.titleA biomarker and therapeutical target in immune thrombocytopenia: TNF receptor-associated factor 6en_US
dc.typeArticleen_US

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