Gastroprotective activity of Nigella sativa L oil and its constituent, thymoquinone against acute alcohol-induced gastric mucosal injury in rats

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dc.authoridOzbek, hanefi/0000-0002-8084-7855;
dc.authorwosidOzbek, hanefi/O-3472-2019
dc.authorwosidözbek, hanefi/P-3492-2015
dc.contributor.authorKanter, Mehmet
dc.contributor.authorDemir, Halit
dc.contributor.authorKarakaya, Cengiz
dc.contributor.authorOzbek, Hanefi
dc.date.accessioned2024-06-12T11:09:13Z
dc.date.available2024-06-12T11:09:13Z
dc.date.issued2005
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAIM: To evaluate the role of reactive oxygen species in the pathogenesis of acute ethanol-induced gastric mucosal lesions and the effect of Nigella sativa L oil (NS) and its constituent thymoquinone (TQ) in an experimental model. METHODS: Male Wistar albino rats were assigned into 4 groups. Control group was given physiologic saline orally (10 mL/kg body weight) as the vehicle (gavage); ethanol group was administrated 1 mL (per rat) absolute alcohol by gavage; the third and fourth groups were given NS (10 mL/kg body weight) and TQ (10 mg/kg body weight p.o) respectively 1 h prior to alcohol intake. One hour after ethanol administration, stomach tissues were excised for macroscopic examination and biochemical analysis. RESULTS: NS and TQ could protect gastric mucosa against the injurious effect of absolute alcohol and promote ulcer healing as evidenced from the ulcer index (UI) values. NS prevented alcohol-induced increase in thiobarbituric acid-reactive substances (TBARS), an index of lipid peroxidation. NS also increased gastric glutathione content (GSH), enzymatic activities of gastric superoxide dismutase (SOD) and glutathione-S-transferase (GST). Likewise, TQ protected against the ulcerating effect of alcohol and mitigated most of the biochemical adverse effects induced by alcohol in gastric mucosa, but to a lesser extent than NS. Neither NS nor TQ affected catalase activity in gastric tissue. CONCLUSION: Both NS and TQ, particularly NS can partly protect gastric mucosa from acute alcohol-induced mucosal injury, and these gastroprotective effects might be induced, at least partly by their radical scavenging activity. (C) 2005 The WJG Press and Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.3748/wjg.v11.i42.6662
dc.identifier.endpage6666en_US
dc.identifier.issn1007-9327
dc.identifier.issn2219-2840
dc.identifier.issue42en_US
dc.identifier.pmid16425361en_US
dc.identifier.scopus2-s2.0-30444448245en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage6662en_US
dc.identifier.urihttps://doi.org/10.3748/wjg.v11.i42.6662
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22728
dc.identifier.volume11en_US
dc.identifier.wosWOS:000208224700016en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBaishideng Publishing Group Incen_US
dc.relation.ispartofWorld Journal Of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNigella Sativaen_US
dc.subjectThymoquinoneen_US
dc.subjectUlceren_US
dc.subjectAnti-Oxidanten_US
dc.subjectRaten_US
dc.titleGastroprotective activity of Nigella sativa L oil and its constituent, thymoquinone against acute alcohol-induced gastric mucosal injury in ratsen_US
dc.typeArticleen_US

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