Effect of Topical Dexamethasone for Preventing Experimentally Induced Myringosclerosis

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dc.authorwosidBULUT, Erdoğan/C-4135-2015
dc.contributor.authorUestuendag, Murat
dc.contributor.authorKocyigit, Murat
dc.contributor.authorBulut, Erdogan
dc.contributor.authorAltaner, Semsi
dc.contributor.authorTas, Abdullah
dc.contributor.authorYagiz, Recep
dc.date.accessioned2024-06-12T11:08:56Z
dc.date.available2024-06-12T11:08:56Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: We aimed to examine the effect of topical dexamethasone by otomicroscopic and histologic examinations for preventing myringosclerosis induced by myringotomy in rat tympanic membranes. Methods: Twenty-one Sprague Dawley rats (42 ears) were randomly divided into the following three groups after otomicroscopic examinations: experimental surgical group (5 rats), control group (8 rats), and study group (8 rats). The rats of all the groups underwent myringotomy in both tympanic membranes. Other than myringotomy, no additional procedure was performed for the rats in the experimental surgical group. In the control group, 0.9% NaCl was applied to the ears, whereas in the study groups, topical dexamethasone was applied to the ears. These applications in the control and study groups were repeated for nine days. On the 10th day of the study, the rat ears of all groups underwent otomicroscopic and histologic examinations. The prevalence and process of myringosclerosis were evaluated by otomicroscopic examination, whereas inflammation, membrane thickness, and myringosclerosis intensity were evaluated by histologic examination. Results: The growth of myringosclerosis with otomicroscopic examination was lesser in the study group in which topical dexamethasone was applied than the control and experimental surgical groups. Moreover, it was observed that myringosclerosis effected less quadrants in the study group. Histologic examinations revealed that inflammation was significantly lesser in the study group than in the experimental surgical and control groups. The average membrane thickness values were significantly lesser in the study group than in the experimental surgical group. With respect to myringosclerosis growth, no statistically significant difference was observed among all groups, whereas with respect to myringosclerosis intensity, the rat ears in the study group were less severely affected. Conclusion: Thus, our study results suggest that applying topical dexamethasone after myringotomy has positive effects on limiting the intensity and prevalence of myringosclerosis.en_US
dc.identifier.doi10.5152/tao.2017.2077
dc.identifier.endpage9en_US
dc.identifier.issn2667-7466
dc.identifier.issn2667-7474
dc.identifier.issue1en_US
dc.identifier.pmid29392044en_US
dc.identifier.startpage3en_US
dc.identifier.urihttps://doi.org/10.5152/tao.2017.2077
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22615
dc.identifier.volume55en_US
dc.identifier.wosWOS:000398921800002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofTurkish Archives Of Otorhinolaryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMyringotomyen_US
dc.subjectDexamethasoneen_US
dc.subjectMyringosclerosisen_US
dc.subjectAnimal Modelen_US
dc.subjectSecretory Otitis-Mediaen_US
dc.subjectMiddle-Earen_US
dc.subjectTympanic Membraneen_US
dc.subjectN-Acetylcysteineen_US
dc.titleEffect of Topical Dexamethasone for Preventing Experimentally Induced Myringosclerosisen_US
dc.typeArticleen_US

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