Preventive effects of curcumin on different aspiration material-induced lung injury in rats

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dc.authoridErel, Tamer/0000-0001-9293-8650
dc.authoridKonukoglu, Dildar/0000-0002-6095-264X
dc.authoridUzun, Hafize/0000-0002-1347-8498
dc.authoridbasaran, umit nusret/0000-0002-9977-6655
dc.authorwosidGuzel, Ahmet/AGE-2880-2022
dc.authorwosidErel, Tamer/AAO-4695-2020
dc.authorwosidKonukoglu, Dildar/D-4951-2019
dc.authorwosidUzun, Hafize/D-4811-2019
dc.contributor.authorGuzel, Ahmet
dc.contributor.authorKanter, Mehmet
dc.contributor.authorAksu, Burhan
dc.contributor.authorBasaran, Umit Nusret
dc.contributor.authorYalcin, Oemer
dc.contributor.authorGuzel, Aygul
dc.contributor.authorUzun, Hafise
dc.date.accessioned2024-06-12T11:13:07Z
dc.date.available2024-06-12T11:13:07Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractWe have studied whether curcumin protects different pulmonary aspiration material-induced lung injury in rats. The experiments were designed in 60 Sprague-Dawley rats, randomly allotted into one of six groups (n = 10): normal saline (NS, control), enteral formula (Biosorb Energy Plus, BIO), hydrochloric acid (HCl), NS + curcumin-treated, BIO + curcumin-treated, and HCl + curcumin-treated. NS, BIO, HCl were injected in to the lungs. The rats received curcumin twice daily only for 7 days. Seven days later, both lungs in all groups were examined histopathologically, immunohistochemically, and biochemically. Histopathologic examination was performed according to the presence of peribronchial inflammatory cell infiltration, alveolar septal infiltration, alveolar edema, alveolar exudate, alveolar histiocytes, interstitial fibrosis, granuloma, and necrosis formation. Immunohistochemical assessments were examined for the activity of inducible nitric oxide synthase (iNOS) and the expression of surfactant protein D (SP-D). Malondialdehyde (MDA), hydroxyproline (HP), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) activity were measured in the lung tissue. Our findings show that curcumin inhibits the inflammatory response reducing significantly (P < 0.05) all histopathological parameters in different pulmonary aspiration models. Pulmonary aspiration significantly increased the tissue HP content, MDA levels and decreased the antioxidant enzyme (SOD, GSH-Px) activities. Curcumin treatment significantly decreased the elevated tissue HP content, and MDA levels and prevented inhibition of SOD, and GSH-Px enzymes in the tissues. Furthermore, our data suggest that there is a significant reduction in the activity of iNOS and a rise in the expression of SP-D in lung tissue of different pulmonary aspiration models with curcumin therapy. Our findings support the use of curcumin as a potential therapeutic agent in acute lung injury.en_US
dc.identifier.doi10.1007/s00383-008-2282-x
dc.identifier.endpage92en_US
dc.identifier.issn0179-0358
dc.identifier.issn1437-9813
dc.identifier.issue1en_US
dc.identifier.pmid19002695en_US
dc.identifier.scopus2-s2.0-57649240408en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage83en_US
dc.identifier.urihttps://doi.org/10.1007/s00383-008-2282-x
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23430
dc.identifier.volume25en_US
dc.identifier.wosWOS:000261692300014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Surgery Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPulmonary Aspirationen_US
dc.subjectAcute Lung Injuryen_US
dc.subjectSurfactant Protein Den_US
dc.subjectInosen_US
dc.subjectCurcuminen_US
dc.subjectAntioxidanten_US
dc.subjectRespiratory-Distress-Syndromeen_US
dc.subjectSurfactant Protein-Den_US
dc.subjectNitric-Oxide Synthaseen_US
dc.subjectNecrosis-Factor-Alphaen_US
dc.subjectAcid Aspirationen_US
dc.subjectPulmonary Aspirationen_US
dc.subjectPneumoniaen_US
dc.subjectMiceen_US
dc.subjectAssayen_US
dc.subjectPentoxifyllineen_US
dc.titlePreventive effects of curcumin on different aspiration material-induced lung injury in ratsen_US
dc.typeArticleen_US

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