Can Age at Diagnosis and Sex Improve the Performance of the American Thyroid Association Risk Stratification System for Prediction of Structural Persistent and Recurrent Disease in Patients With Differentiated Thyroid Carcinoma? A Multicenter Study

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dc.authoridKadioglu, Pinar/0000-0002-8329-140X
dc.authoridElbuken, Gulsah/0000-0002-0920-6895;
dc.authorwosidKadioglu, Pinar/AAM-9935-2020
dc.authorwosidElbuken, Gulsah/ABD-5689-2020
dc.authorwosidAVCI, UĞUR/ABG-8754-2021
dc.authorwosidBayraktaroglu, Taner/Y-8182-2019
dc.authorwosidTekin, Sakin/HJP-0599-2023
dc.contributor.authorZuhur, Sayid Shafi
dc.contributor.authorAggul, Hunkar
dc.contributor.authorCelik, Mehmet
dc.contributor.authorAvci, Ugur
dc.contributor.authorErol, Selvinaz
dc.contributor.authorKilinc, Faruk
dc.contributor.authorAkbaba, Gulhan
dc.date.accessioned2024-06-12T10:52:44Z
dc.date.available2024-06-12T10:52:44Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Although the age at diagnosis has been suggested as a major determinant of disease-specific survival in the recent TNM staging system, it is not included in the recent American Thyroid Association (ATA) guidelines to estimate the risk of recurrence. Nevertheless, the effect of sex on differentiated thyroid carcinoma (DTC) recurrence is controversial. Therefore, this multicenter study was conducted to assess whether age at diagnosis and sex can improve the performance of the ATA 3-tiered risk stratification system in patients with DTC with at least 5 years of follow-up. Methods: In this study, the computer-recorded data of the patients diagnosed with DTC between January 1985 and January 2016 were analyzed. Only patients with proven structural persistent/recurrent disease were selected for comparisons. Results: This study consisted of 1691 patients (female, 1367) with DTC. In Kaplan-Meier analysis, disease-free survival (DFS) was markedly longer in females only in the ATA low-risk category (P = .045). Nevertheless, a markedly longer DFS was observed in patients aged <45 years in the ATA low- and intermediate-risk categories (P = .004 and P = .009, respectively), whereas in patients aged <55 years, DFS was markedly longer only in the ATA low-risk category (P < .001). In the Cox proportional hazards model, ages of >45 and >55 years at diagnosis and the ATA risk stratification system were all independent predictors of persistent/recurrent disease. Conclusion: Applying the age cutoff of 45 years in the ATA intermediate- and low-risk categories may identify patients at a higher risk of persistence/recurrence and may improve the performance of the ATA risk stratification system, whereas sex may improve the performance of only the ATA low-risk category. (c) 2021 AACE. Published by Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.eprac.2021.09.001
dc.identifier.endpage35en_US
dc.identifier.issn1530-891X
dc.identifier.issn1934-2403
dc.identifier.issue1en_US
dc.identifier.pmid34508902en_US
dc.identifier.scopus2-s2.0-85116843233en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage30en_US
dc.identifier.urihttps://doi.org/10.1016/j.eprac.2021.09.001
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18808
dc.identifier.volume28en_US
dc.identifier.wosWOS:000741473100006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Incen_US
dc.relation.ispartofEndocrine Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectATA Risk Strati Fication Systemen_US
dc.subjectDifferentiated Thyroid Canceren_US
dc.subjectRecurrenceen_US
dc.subjectSexen_US
dc.subjectAgeen_US
dc.subjectStaging Systemen_US
dc.subjectCanceren_US
dc.subjectManagementen_US
dc.subjectTherapyen_US
dc.subjectCutoffen_US
dc.titleCan Age at Diagnosis and Sex Improve the Performance of the American Thyroid Association Risk Stratification System for Prediction of Structural Persistent and Recurrent Disease in Patients With Differentiated Thyroid Carcinoma? A Multicenter Studyen_US
dc.typeArticleen_US

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