The short-term effects of single toxic citric acid doses on mouse tissues - Histopathological study

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dc.authoridCerkezkayabekir, Aysegul/0000-0001-5537-1042;
dc.authorwosidCerkezkayabekir, Aysegul/Q-6629-2018
dc.authorwosidBAKAR, Elvan/AAE-9247-2022
dc.contributor.authorAktac, Tulin
dc.contributor.authorKaboglu, Aysegul
dc.contributor.authorKizilay, Gulnur
dc.contributor.authorBakar, Elvan
dc.date.accessioned2024-06-12T10:56:35Z
dc.date.available2024-06-12T10:56:35Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIn this study, the acute-toxic effects of citric acid, a food preservative, were histopathologically investigated on the liver and kidney tissues of mice. A LD25 (480 mg/kg body weight) dose of citric acid was given by intraperitoneal injection, and after ten days several necrotic changes were observed in both tissues by light and electron microscopy. Citric acid treatment caused loosing and combining of hepatocyte membranes; cytoplasmic vacuolization in hepatocytes; picnotic nuclei; mononuclear cell infiltration in small areas, and degeneration of blood vessel endothelium in liver; damaging of cell membrane; picnotic nuclei and hypertrophy of lining epithelium of tubules; disappearing of basal membrane and fusing of tubules in kidney. It also caused a decrease in numbers and volume of mitochondria and increase in secondary lysosomes, disorganization and loss of mitochondrial cristae in both tissues, invagination of nucleus membrane in liver, disorder of basal infoldings, swelling in endoplasmic reticulum sacs and loss of junctional complex as well as partial separation of tubule cells in kidney. The results suggest that citric acid dose level has toxic effects in mice, and additional toxic properties must be examined in detail.en_US
dc.identifier.endpage315en_US
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-43749121835en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage311en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19848
dc.identifier.volume17en_US
dc.identifier.wosWOS:000255898400007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherParlar Scientific Publications (P S P)en_US
dc.relation.ispartofFresenius Environmental Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCitric Aciden_US
dc.subjectFood Additiveen_US
dc.subjectKidneyen_US
dc.subjectLiveren_US
dc.subjectHistopathologyen_US
dc.subjectSodium Metabisulfiteen_US
dc.subjectFood Preservativesen_US
dc.subjectRatsen_US
dc.subjectCytotoxicityen_US
dc.subjectGenotoxicityen_US
dc.subjectAntioxidanten_US
dc.subjectBenzoateen_US
dc.subjectParabenen_US
dc.titleThe short-term effects of single toxic citric acid doses on mouse tissues - Histopathological studyen_US
dc.typeArticleen_US

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