Prostatic acid phosphatase in breast cyst fluid.

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dc.authorscopusid6602412924
dc.authorscopusid20733795800
dc.authorscopusid6506740751
dc.contributor.authorErbas H.
dc.contributor.authorErten O.
dc.contributor.authorIrfanoglu M.E.
dc.date.accessioned2024-06-12T10:27:59Z
dc.date.available2024-06-12T10:27:59Z
dc.date.issued2007
dc.description.abstractProstatic Acid Phosphatase (PAP) is mostly found in the epithelial cells and secretions of the prostate gland. It has also been found to be present in several tissues and biological fluid. Gross cystic breast disease is the commonest benign breast condition and several studies have shown that women with palpable breast cysts may have a higher risk of developing breast cancer. There are two types of breast cyst and women with apocrine breast cyst may have a higher risk of developing breast cancer than women with breast cysts lined by flattened epithelium. The growth inhibitory effect of transforming growth factor beta (TGF-beta) on epithelial cells suggests a potential protective role in breast cancer. TGF-beta is secreted as a high molecular weight complex in a biologically inactive or latent form and activation of TGF-beta is necessary for the exertion of its effects on target cells. Prostate specific antigen (PSA) has been found in breast cyst fluid (BCF) and it may have a protective effect on the development of several carcinomas by activating TGF-beta. As a similar molecule to PSA, PAP may also involve in this mechanism. We investigated the presence of PAP in two groups of BCF using an ELISA kit. PAP was found to be present in BCF but there was not a statistically significant difference between the two cyst groups. The presence of PAP in BCF may suggest its possible role in the development of breast cancer from cystic breast diseases. A possible role of PAP on TGF-beta activation needs further investigation.en_US
dc.identifier.endpage99en_US
dc.identifier.issn0126-8635
dc.identifier.issue2en_US
dc.identifier.pmid19108401en_US
dc.identifier.scopus2-s2.0-59149091308en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage95en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17030
dc.identifier.volume29en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofThe Malaysian journal of pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcid Phosphatase Prostate Isoenzyme; Protein Tyrosine Phosphatase; Article; Breast Cyst; Chemistry; Cyst Fluid; Enzyme Linked Immunosorbent Assay; Enzymology; Female; Human; Pathology; Breast Cyst; Cyst Fluid; Enzyme-Linked Immunosorbent Assay; Female; Humans; Protein Tyrosine Phosphatasesen_US
dc.titleProstatic acid phosphatase in breast cyst fluid.en_US
dc.typeArticleen_US

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