The Effects of NT and Adjuvant Treatments on Anastomotic Leakage in Rectal Cancer

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dc.contributor.authorAsratova, Nigara
dc.contributor.authorCakcak, İbrahim Ethem
dc.contributor.authorCoşkun, İrfan
dc.date.accessioned2024-06-12T10:05:21Z
dc.date.available2024-06-12T10:05:21Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAim: Anastomosis leakage (AL) is a major complication following colorectal surgery. The present study aims to investigate the effects of adjuvant (AT) and neoadjuvant (NT) treatments on AL in surgical patients with rectal cancer. Method: The study followed 319 patients (age >18 years) who were diagnosed with rectal cancer and underwent surgery with AT or NT treatment between January 1, 2010 and December 31, 2018. We evaluated demographic data, tumor stage, metastasis status, organ and lymph node involvement, surgery type, use of AT and NT, the presence of AL, mortality status, and serum carcinoembryonic antigen levels. Results: A total of 179 (56.1%) patients were male, 140 (43.9%) were female (mean age =58.6±13.2 years). In terms of additional treatment, 48.6% (n=155) received AT and 51.4% (n=164) received NT. Data revealed that 13.1% (n=42) of the patients received only radiotherapy (RT), 10.6% (n=34) received only chemotherapy (CT), and 76.2% (n=243) received both RT and CT (CRT). Additionally, 23.5% (n=75) of the patients had AL. In terms of AL frequency, we found no difference between the patients receiving AT or NT (p=0.758). Additionally, RT and CT had no effect on the development of AL (p=0.827 and p=0.1, respectively). Finally, mortality was not higher in patients with AL. Conclusion: In terms of AL development, we found no differences between patients receiving NT or AT and those using RT or CT alone or together. We recommend that these rectal cancer treatments should be continued because of their better local control, overall survival rate, and sphincter function preservation rates.en_US
dc.identifier.doi10.4274/tjcd.galenos.2021.2020-10-6
dc.identifier.endpage190en_US
dc.identifier.issn2536-4898
dc.identifier.issn2536-4901
dc.identifier.issue3en_US
dc.identifier.startpage182en_US
dc.identifier.trdizinid506102en_US]
dc.identifier.urihttps://doi.org/10.4274/tjcd.galenos.2021.2020-10-6
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/506102
dc.identifier.urihttps://hdl.handle.net/20.500.14551/13395
dc.identifier.volume31en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTürk Kolon ve Rektum Hastalıkları Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe Effects of NT and Adjuvant Treatments on Anastomotic Leakage in Rectal Canceren_US
dc.typeArticleen_US

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