Increased frequency of class I and II anti-human leukocyte antigen antibodies in systemic lupus erythematosus and scleroderma and associated factors: a comparative study

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dc.authoridYazar, Metin/0000-0002-2657-3072
dc.authoridGürkan, Hakan/0000-0002-8967-6124
dc.authoridSARI, Gulce/0000-0002-8585-5889
dc.authorwosidYazar, Metin/ABA-3934-2020
dc.authorwosidGürkan, Hakan/AAF-2866-2020
dc.contributor.authorTozkir, Hilmi
dc.contributor.authorPamuk, Omer Nuri
dc.contributor.authorDuymaz, Julide
dc.contributor.authorGurkan, Hakan
dc.contributor.authorYazar, Metin
dc.contributor.authorSari, Gulce
dc.contributor.authorTanrikulu, Hazel
dc.date.accessioned2024-06-12T10:51:58Z
dc.date.available2024-06-12T10:51:58Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAim: There is significant autoantibody production in systemic lupus erythematosus (SLE) and scleroderma (SSc); microchimerism is also thought to play a role in pathogenesis. We determined the frequency of anti-HLA antibodies in SLE and SSc patients and evaluated associated clinical factors. Methods: We included 77 SLE patients, 46 SSc patients and 53 healthy controls into the study. Clinical data about the patients were obtained from hospital records. Anti-human leukocyte (anti-HLA) antigen antibody analysis of sera was performed by applying Lifecodes anti-HLA Class I and Class II Screening kits based on xMAP technology. Results: The frequencies of class I and II anti-HLA antibodies were significantly higher in SLE (27.3% and 41.6%) and SSc (26.1% and 41.3%) groups than in healthy controls (1.9% and 5.7%) (all P < 0.001). Frequencies of thrombocytopenia (P = 0.021), anti-ribonucleoprotein (P = 0.037) and anti-Ro (P = 0.027) were significantly higher in the class I antibody-positive SLE group; however, pericarditis was less frequent (P = 0.05). On the other hand, the class II antibody-positive SLE group had more frequent anti-ribosomal P antibody (P = 0.038), but less frequent active disease (P = 0.038). In the SSc group, class I antibody-positive patients had more frequent digital ulcers (P = 0.048) and anti-centromere antibodies (P = 0.01). There was no association of anti-HLA antibodies with pulmonary hypertension and interstitial fibrosis in SSc patients. Conclusions: Both class I and class II antibodies were found to be significantly increased in SLE and SSc. Rather than major organ involvement, anti-HLA antibodies were associated with the presence of other antibodies in both diseases.en_US
dc.description.sponsorshipTrakya University Scientific Research Fund (TUBAP), Edirne, Turkeyen_US
dc.description.sponsorshipThis study was supported by a grant from the Trakya University Scientific Research Fund (TUBAP), Edirne, Turkey.en_US
dc.identifier.doi10.1111/1756-185X.12484
dc.identifier.endpage1309en_US
dc.identifier.issn1756-1841
dc.identifier.issn1756-185X
dc.identifier.issue12en_US
dc.identifier.pmid25292400en_US
dc.identifier.scopus2-s2.0-84910604305en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1304en_US
dc.identifier.urihttps://doi.org/10.1111/1756-185X.12484
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18556
dc.identifier.volume19en_US
dc.identifier.wosWOS:000398230800012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal Of Rheumatic Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnti-HLA Class I Antibodyen_US
dc.subjectAnti-HLA Class II Antibodyen_US
dc.subjectSclerodermaen_US
dc.subjectSystemic Lupus Erythematosusen_US
dc.subjectHla Antibodiesen_US
dc.subjectChronic Rejectionen_US
dc.subjectMicrochimerismen_US
dc.subjectBronchiolitisen_US
dc.subjectChimerismen_US
dc.subjectCriteriaen_US
dc.subjectWomenen_US
dc.titleIncreased frequency of class I and II anti-human leukocyte antigen antibodies in systemic lupus erythematosus and scleroderma and associated factors: a comparative studyen_US
dc.typeArticleen_US

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